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Systems biology towards novel chronic kidney disease diagnosis and treatment

Objective

Chronic kidney disease (CKD) affects up to 10% of the population. Besides eventual progression towards end stage renal disease CKD impacts the patient’s quality of life by causing serious comorbidities including cardiovascular complications and bone metabolism disorders. On the everyday clinical level early stage diagnosis and tailored treatment of CKD are still inadequate. In addition, CKD seems not to have reached its appropriate emplacement in an epidemiological and healthcare perspective yet, and the pathophysiology of the disease on a molecular and cellular level is not well enough understood. Our sysKID consortium was installed for precisely addressing these issues: To unravel the molecular and cellular mechanisms of chronic kidney disease development, combine this information with clinical risk factors, and on this basis delineate chronic kidney disease biomarkers. These markers will allow us to perform preclinical studies of novel therapy approaches for halting disease progression, and will provide us with the materials for development and clinical evaluation of tools for early stage diagnosis as well as prognosis and treatment monitoring. sysKID assures a successful implementation of these goals by a truly international consortium of 27 leading research groups. We combine clinical know how, provide access to a huge chronic kidney disease sample and clinical data pool, and build a Systems Biology framework for chronic kidney disease by integrating molecular and cellular biology, computational biology, statistics and epidemiology. Our expert group is further complemented by a high level advisory board covering science, product development, and the patient’s perspective. sysKID implementation is structured for completing pre-clinical Proof of Concept studies of novel chronic kidney disease therapy regimes, and further for completing clinical evaluation of an epidemiological screening tool as well as of early stage chronic kidney disease diagnostic kits.

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Coordinator

EMERGENTEC BIODEVELOPMENT GMBH
Address
Gersthofer Strasse 29-31
1180 Vienna
Austria
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 816 380
Administrative Contact
Bernd Mayer (Dr.)

Participants (28)

UNIVERSITE VICTOR SEGALEN BORDEAUX II

Participation ended

France
Address
Rue Leo Saignat 146
33076 Bordeaux Cedex
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rachid Salmi (Prof.)
MEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 965 360
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rainer Oberbauer (Prof.)
MEDIZINISCHE UNIVERSITAT INNSBRUCK
Austria
EU contribution
€ 1 526 360
Address
Christoph Probst Platz 1
6020 Innsbruck
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sonja Schmidl (Dr.)
MOSAIQUES DIAGNOSTICS GMBH
Germany
EU contribution
€ 662 140
Address
Rotenburger Strasse 20
30659 Hannover
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Harald Mischak (Prof.)
ProScience Communications - die Agentur fur Wissenschaftskommunikation GmbH
Germany
EU contribution
€ 114 000
Address
Andechser Weg 17
82343 Poecking
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Barbara Ritzert (Ms.)
NOVO NORDISK INVEST 4 A/S
Denmark
EU contribution
€ 336 672
Address
Novo Alle 1
2880 Bagsvaerd
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Peter Rossing (Dr.)
UNIVERSITATSKLINIKUM ERLANGEN
Germany
EU contribution
€ 336 160
Address
Maximiliansplatz 2
91054 Erlangen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katrin Faber (Dr.)
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 620 120
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dick De Zeeuw (Prof.)
SLASKI UNIWERSYTET MEDYCZNY W KATOWICACH
Poland
EU contribution
€ 166 240
Address
Ul. Poniatowskiego 15
40 055 Katowice
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andrzej Wiecek (Prof.)
SEMMELWEIS EGYETEM
Hungary
EU contribution
€ 166 240
Address
Ulloi Utca 26
1085 Budapest
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Laszlo Rosivall (Prof.)
UNIVERSITY OF GLASGOW
United Kingdom
EU contribution
€ 166 240
Address
University Avenue
G12 8QQ Glasgow
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Derek Motherwell (Mr.)
BIOCRATES LIFE SCIENCES AG
Austria
EU contribution
€ 288 120
Address
Eduard Bodem Gasse 8 1 Stock
6020 Innsbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ourania Kovaiou (Dr.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 924 920
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eveline Fräßdorf (Ms.)
BIOGAZELLE NV
Belgium
EU contribution
€ 417 060
Address
Technologiepark 82
9052 Zwijnaarde
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jo Vandesompele (Prof.)
CELERA CORPORATION
United States
EU contribution
€ 258 000
Address
Centerville Road - Suite 400 2711
19808 Wilmington
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Dov Shiffman (Dr.)
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 385 160
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Clementia C.M. Kranendonk-Van Der Ploeg (Ms.)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 186 614
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
Administrative Contact
Salvatore Capria (Dr.)
UNIVERSITE DE BORDEAUX
France
EU contribution
€ 261 160
Address
Place Pey Berland 35
33000 Bordeaux
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rachid Salmi (Prof.)
WEIZMANN INSTITUTE OF SCIENCE
Israel
EU contribution
€ 506 716
Address
Herzl Street 234
7610001 Rehovot
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Talia Tzahor (Ms.)
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
EU contribution
€ 485 500
Address
Belfield
4 Dublin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Donal Doolan (Mr.)
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
EU contribution
€ 457 160
Address
Via Mario Negri 2
20156 Milano
Activity type
Research Organisations
Administrative Contact
Maria Grazia Pezzoni (Ms.)
UNIVERSITAT DES SAARLANDES
Germany
EU contribution
€ 455 720
Address
Campus
66123 Saarbrucken
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Vera Siegmund (Dr.)
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE

Participation ended

Spain
Address
Avenida Gran Via Hospitalet 199-203
08908 L'hospitalet De Llobregat
Activity type
Research Organisations
Administrative Contact
Victoria Cochrane (Ms.)
AMGEN (EUROPE) GMBH
Switzerland
EU contribution
€ 31 200
Address
Dammstrasse 23
6300 Zug
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Mourad Farouk (Dr.)
THE ANTIBODY LAB GMBH
Austria
EU contribution
€ 446 800
Address
Divischgasse 4
1210 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Renate Berger-Mostler (Ms.)
UNIVERSIDAD DE CORDOBA
Spain
EU contribution
€ 226 800
Address
Avenida De Medina Azahara 5
14005 Cordoba
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Carmen Tarradas Iglesias (Prof.)
INSTITUT CATALA DE LA SALUT
Spain
EU contribution
€ 457 052
Address
Gran Via De Les Corts Catalanes 587
08007 Barcelona
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Laia Lagunas (Ms.)
UNIVERSITAETSKLINIKUM AACHEN
Germany
EU contribution
€ 125 640
Address
Pauwelsstrasse 30
52074 Aachen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Volker Legewie (Mr.)