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'Systems' study of cellular growth, shape and polarity

Objective

A major challenge of modern biology is to elucidate how cellular structure and function result from the systemic action of the genome and proteome. In this proposal, we describe an integrated approach combining high-content and quantitative microscopy, systematic gene knockouts, and computational/theoretical methods to carry out the most detailed systemic study of three key aspects of cell physiology: growth, shape and polarity. We will use the fission yeast Schizosaccharomyces pombe as experimental model organism. The haploid fission yeast with its relative genomic simplicity, genetic tractability, uniform size and shape, and well-characterized, conserved and simple growth and polarization machinery is ideal for this study. A better understanding of the systemic regulation of those processes is likely to contribute in the long run to the development of better strategies to fight cellular pathologies associated with many diseases, such as cancer.

Field of science

  • /medical and health sciences/basic medicine/pathology
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /natural sciences/biological sciences/genetics and heredity/genome
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics
  • /medical and health sciences/basic medicine/physiology

Call for proposal

ERC-2009-StG
See other projects for this call

Funding Scheme

ERC-SG - ERC Starting Grant

Host institution

THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 697 400
Principal investigator
Rafael Edgardo Carazo Salas (Dr.)
Administrative Contact
Renata Schaeffer (Ms.)

Beneficiaries (1)

THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 1 697 400
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Principal investigator
Rafael Edgardo Carazo Salas (Dr.)
Administrative Contact
Renata Schaeffer (Ms.)