CORDIS
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Nucleosome Structure & Function across Biological Scales and Biological Function

Project information

Grant agreement ID: 238176

Status

Closed project

  • Start date

    1 November 2009

  • End date

    31 October 2013

Funded under:

FP7-PEOPLE

  • Overall budget:

    € 4 609 511

  • EU contribution

    € 4 609 511

Coordinated by:

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

Objective

Chromatin packages a few meters of DNA into a nucleus measuring a few microns. This tight folding occurs by assembling DNA with histones into so-called nucleosomes, thus ensuring the mechanical stability of our genome. On the flipside, this makes nucleosomes a formidable obstacle to the machines that read, copy or repair its DNA message. One of the fundamental questions in biology is to understand how nucleosome structure is established, maintained and manipulated. Our Marie Curie Initial Training Network will carry out multidisciplinary, collaborative research projects focused on deciphering nucleosome structure and function in space and time (Nucleosome4D). Our main objective is to provide our young researchers with world-class research & training in nucleosome biology. We will use cutting-edge, interdisciplinary methods and collaborative projects to determine how nucleosomes are remodeled during transcription, when genes are silenced, as cell divide, as stem cells differentiate, during organismal development and in human disease. We utilize state-of-the-art approaches in structural biology, biophysics, cell biology, live-cell imaging, biochemistry, genetics, genomics and bioinformatics. We will implement a comprehensive training plan for scientific and career development using the best local approaches to research & training, by promoting exchanges, using the advise of our industrial partners and three Visiting Scientists, by sharing reagents and expertise, as well as through a structured set of scientific workshops and complementary skills training courses. Together, our effort will ensure the multidisciplinary and intersectorial training of a new cohort of young European researchers. This will allow our trainees to take the opportunities and meet the challenges of a successful career in the life science sector through excellent training, effective communication, great teamwork and proven project management skills.

Coordinator

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Address

Geschwister Scholl Platz 1
80539 Muenchen

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 506 963

Administrative Contact

Corey Laverty (Dr.)

Participants (16)

UNIVERSITETET I BERGEN

Norway

EU Contribution

€ 239 327

INSTITUT CURIE

France

EU Contribution

€ 382 193

SZEGEDI TUDOMANYEGYETEM

Hungary

EU Contribution

€ 148 589

Novartis Forschungsstiftung

Switzerland

EU Contribution

€ 648 355

KOBENHAVNS UNIVERSITET

Denmark

EU Contribution

€ 243 112

FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

Spain

EU Contribution

€ 189 389

MEDIZINISCHE UNIVERSITAT INNSBRUCK

Austria

EU Contribution

€ 199 392

THE HEBREW UNIVERSITY OF JERUSALEM

Israel

EU Contribution

€ 190 019

UNIVERSITY OF DUNDEE

United Kingdom

EU Contribution

€ 208 275

MEDICAL RESEARCH COUNCIL

United Kingdom

EU Contribution

€ 208 775

CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE

France

EU Contribution

€ 201 684

Cambridge Cell Networks Ltd

United Kingdom

EU Contribution

€ 208 275

HMGBiotech s.r.l.

Italy

EU Contribution

€ 181 883

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

EU Contribution

€ 393 008

JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN

Germany

EU Contribution

€ 198 004

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

EU Contribution

€ 262 268

Project information

Grant agreement ID: 238176

Status

Closed project

  • Start date

    1 November 2009

  • End date

    31 October 2013

Funded under:

FP7-PEOPLE

  • Overall budget:

    € 4 609 511

  • EU contribution

    € 4 609 511

Coordinated by:

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany