Skip to main content

Regenerating Bone defects using New biomedical Engineering approaches

Objective

Bone is among the most frequently transplanted tissue with about 1 million procedures annually in Europe. The worldwide market of bone replacement materials is currently estimated at 5 billion € with a 10% annual growth. Despite their considerable disadvantages, including the risk of disease transfer and immunologic rejection, limited supply of bone, costs and complications, allografts and autografts account for more than 80% of total graft volume. Significant growth opportunities exist for synthetic bone grafts in association with mesenchymal stem cells from autologous or allogenic sources as alternatives to biological bone grafts in orthopaedic and maxillofacial surgery. The objectives of REBORNE is to perform clinical trials using advanced biomaterials and cells triggering bone healing in patients. In order to reach this goal, five phase II clinical studies with 20 patients are proposed in 12 clinical centres spread in 8 European countries. Three orthopaedic trials concerning the treatment of long bone fractures and osteonecrosis of the femoral head in adults or children will be conducted using bioceramics, hydrogel for percuteneous injection and stem cells from autologous or allogenic sources. Clinical research will also concern maxillofacial surgery with bone augmentation prior to dental implants and the reconstruction of cleft palates in children. The safety and efficacy of the new therapies will be assessed clinically using X-rays, CT scans and MRI as well as histology of biopsies. These ambitious clinical targets will require research and development efforts from a large consortium of top world class laboratories, SMEs manufacturing biomaterials, GMP-cell producing facilities and surgeons in hospitals as well as the consideration of ethical and regulatory issues. It is expected that REBORNE will expand the competitiveness of Europe through the patenting of new CE-marked bioproducts in the field of regenerative medicine.

Field of science

  • /medical and health sciences/medical biotechnology
  • /medical and health sciences/clinical medicine/orthopaedics

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Rue De Tolbiac 101
75654 Paris
France
Activity type
Research Organisations
EU contribution
€ 2 121 051,08
Administrative Contact
Marianne Desmedt (Ms.)

Participants (23)

ETABLISSEMENT FRANCAIS DU SANG
France
EU contribution
€ 1 439 351,40
Address
Avenue Du Stade De France 20
93210 La Plaine Saint Denis
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Laurent Beauverger (Mr.)
BIOMATLANTE
France
EU contribution
€ 477 500
Address
5 Rue Edouard Belin - Za Des Iv Nations
44360 Vigneux De Bretagne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Isabelle Bocherel (Ms.)
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 224 994
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
Administrative Contact
Nathalie Rouas-Freiss (Dr.)
FONDAZIONE IRCCS CA' GRANDA - OSPEDALE MAGGIORE POLICLINICO
Italy
EU contribution
€ 546 715,54
Address
Via Francesco Sforza 28
20122 Milano
Activity type
Other
Administrative Contact
Rosaria Giordano (Dr.)
CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES

Participation ended

France
EU contribution
€ 99 892,17
Address
Allee De L'ile Gloriette 5
44093 Nantes
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Annes Brethet (Ms.)
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
EU contribution
€ 121 388
Address
3 Avenue Victoria
75000 Paris
Activity type
Research Organisations
Administrative Contact
Christophe Misse (Mr.)
KITOZYME SA
Belgium
EU contribution
€ 300 160
Address
Rue Haute Claire Parc Industriel 4
4040 Herstal
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Arnaud Hamers (Mr.)
KUROS BIOSCIENCES BV
Netherlands
EU contribution
€ 401 600
Address
Professor Bronkhorstlaan 10 G 48
3723 MB Bilthoven
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Florence De Groot (Dr.)
UNIVERSITAT POLITECNICA DE CATALUNYA
Spain
EU contribution
€ 304 855
Address
Calle Jordi Girona 31
08034 Barcelona
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Pau Ginebra (Prof.)
UNIVERSIDAD AUTONOMA DE MADRID
Spain
EU contribution
€ 630 499,50
Address
Calle Einstein 3 Ciudad Univ Cantoblanco Rectorado
28049 Madrid
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ana Amigo (Ms.)
UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA
Italy
EU contribution
€ 803 109,26
Address
Via Universita 4
41121 Modena
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Guiseppe Torelli (Prof.)
UNIVERSITATEA DE MEDICINA SI FARMACIE VICTOR BABES TIMISOARA
Romania
EU contribution
€ 247 600
Address
Piata Eftimie Murgu 2A
300041 Timisoara
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Constanta Caplar
CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE TOURS
France
EU contribution
€ 112 050
Address
Boulevard Tonelle 2
37044 Tours Cedex 9
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Philippe Rosset (Prof.)
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 465 696
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ingo Müller (Dr.)
UNIVERSITAET ULM
Germany
EU contribution
€ 1 356 006,42
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Gleixner
UNIVERSITA DEGLI STUDI DI VERONA
Italy
EU contribution
€ 481 199,62
Address
Via Dell Artigliere 8
37129 Verona
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Giovanni Menegatti (Dr.)
ALCIMED
France
EU contribution
€ 374 964
Address
Boulevard De Montmorency 57
75016 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
David Bariau (Mr.)
UNIVERSITETET I BERGEN
Norway
EU contribution
€ 409 868,75
Address
Museplassen 1
5020 Bergen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Inger Gjesdahl (Ms.)
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 199 940
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
P.J.A. De Koning (Dr.)
ISTITUTO ORTOPEDICO RIZZOLI
Italy
EU contribution
€ 363 180
Address
Via Di Barbiano 1/10
40136 Bologna
Activity type
Research Organisations
Administrative Contact
Andrea Rizzi (Dr.)
Klinik Max Planck Institut für Psychiatrie
Germany
EU contribution
€ 352 448,86
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Udo Schreiner (Mr.)
AZIENDA OSPEDALIERO-UNIVERSITARIA ANNA MEYER
Italy
EU contribution
€ 88 800
Address
Viale Pieraccini 24
50139 Firenze
Activity type
Research Organisations
Administrative Contact
Franco Bambi (Dr.)
UNIVERSITE DE LIEGE
Belgium
EU contribution
€ 12 470,40
Address
Place Du 20 Aout 7
4000 Liege
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eric Rompen (Prof.)