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Novel immunotherapies for type 1 diabetes

Objective

This proposal will pioneer the concept of tailored interventions with minimal immune system interference in new onset T1DM, leading to beta-cell protection and restoration, based on a solid understanding of the disease pathogenesis. This will enable experimental findings to be adopted for future clinical application. Four work packages are grouped around ‘Reversal of autoimmunity’, in which two key players of the immune system in beta-cell destruction will be targeted: the dendritic cell (WP1: Re-educating antigen-presenting cells) and the T-lymphocyte (WP2: Restoring the T-cell balance). In both cell types, interventions using steroid hormones (vitamin D and glucocorticoids) will be used to induce tolerance. Moreover, novel interventions using soluble T-cell receptors to target immune cells and beta-cells in an antigen-specific way (WP3: TCR-mediated immunotherapy) will be introduced. Novel mucosal interventions using probiotics and recombinant L. lactis as a carrier for specific peptides in combination with cytokines (WP4: Mucosal intervention for tolerance restoration) will be studied for their immune modulating potential. A full work package (WP5: Beta-cell protection and restoration – the dialogue with the immune system) is dedicated to the beta-cell and its role in driving and amplifying the immune attack through communication between beta-cells and the immune system. The last scientific work package (WP6: Pharmacogenetics) will identify genetic profiles within patients that predict responsiveness to the steroid interventions proposed. WP7 and 8 are dedicated to training and management of the consortium. For this purpose, a multidisciplinary consortium of leading European diabetologists and immunologists from 11 academic research institutions, in co-operation with 3 SMEs developing novel technologies allowing translation of basic research results towards clinical applications, has been established.

Field of science

  • /medical and health sciences/clinical medicine/endocrinology/diabetes
  • /medical and health sciences/basic medicine/immunology/immunotherapy
  • /medical and health sciences/basic medicine/immunology

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

KATHOLIEKE UNIVERSITEIT LEUVEN
Address
Oude Markt 13
3000 Leuven
Belgium
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 636 200,80
Administrative Contact
Myriam Witvrouw (Dr.)

Participants (14)

JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN
Germany
EU contribution
€ 650 100
Address
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rolf Draeger (Mr.)
UNIVERSITY OF BRISTOL
United Kingdom
EU contribution
€ 709 845,60
Address
Beacon House Queens Road
BS8 1QU Bristol
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Vince Boyle (Mr.)
FUNDACAO CALOUSTE GULBENKIAN
Portugal
EU contribution
€ 597 300
Address
Avenida Berna 45
1000 Lisboa
Activity type
Research Organisations
Administrative Contact
Jose Mario Leite (Mr.)
UNIVERSITA DEGLI STUDI DI SIENA
Italy
EU contribution
€ 596 100
Address
Via Banchi Di Sotto 55
53100 Siena
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Silvano Focardi (Prof.)
UNIVERSITE LIBRE DE BRUXELLES
Belgium
EU contribution
€ 699 300
Address
Avenue Franklin Roosevelt 50
1050 Bruxelles
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Patrick Goblet (Mr.)
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
EU contribution
€ 928 500
Address
Carl-neuberg-strasse 1
30625 Hannover
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Angela Steinhusen (Ms.)
UNIVERSITA DI PISA
Italy
EU contribution
€ 494 100
Address
Lungarno Pacinotti 43/44
56126 Pisa
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Enio Martino (Prof.)
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 805 299,60
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Labbett (Mr.)
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 1 074 962,40
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sonja Croes De Bruin (Ms.)
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 670 500
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Keith Cann (Mr.)
ActoGeniX NV
Belgium
EU contribution
€ 652 500
Address
Technologiepark 4
9052 Zwijnaarde
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Magda Van Hijfte (Ms.)
DanDrit Biotech A/S

Participation ended

Denmark
EU contribution
€ 62 437,20
Address
Fruebjergvej 3
2100 Copenhagen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Mai-Britt Zocca (Dr.)
Immunocore Limited
United Kingdom
EU contribution
€ 832 500
Address
Milton Park 57C
OX14 4RX Abingdon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Stephen Megit (Dr.)
CARDIFF UNIVERSITY
United Kingdom
EU contribution
€ 511 154,40
Address
Newport Road 30-36
CF24 ODE Cardiff
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nick Bodycombe (Mr.)