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Molecular Targets Open for Regulation by the gut flora – New Avenues for improved Diet to Optimize European health

Objective

Europe is facing major diet related health problems. Attitudes to eating habits have to be changed and the benefits of alternative treatment regimes substantiated. This can only be achieved by providing guidelines regulating health claims based on scientific data. Thus, there is a unique opportunity to use gut flora in potential treatment regimes and as a preventive target for major diet related health problems. TORNADO consortium proposes a systemic and comprehensive mechanistic approach to deliver scientific data that can be compiled as guidelines for European authorities. TORNADO will determine the influence of diet on the gut flora and highlight the impact of gut flora on the immune system/other organ systems. TORNADO aims to investigate molecular targets that are subject to regulation by gut flora and diet that sustain health. This will be done by an increasing level of specificity, from (1) investigations of dietary habits and health in population cohorts, through (2) intervention studies in humans and animals and (3) analyses of the intestine and immune system, and also organs like adipocyte tissue, liver & brain, to pinpointing the impact of dietary influence on (4) cells and (5) potential functional molecular targets. TORNADO will deliver data that can be used to recommend biomarkers for evaluating effects of diet or microbes; refute, substantiate or improve health claims of existing products; generate novel functional food products. TORNADO's approach of microbe-to-mouse-to-man validation of dietary influence will enable more solid evidence for health claims and provide concrete deliverables e.g. Roadmaps to Health, Tailor-made Health-monitoring. Continuous state-of-the-art dissemination programs will increase impact. TORNADO's program will accelerate future design of personalized functional food for specific target groups. The evidence-based data delivered by TORNADO will have long lasting effects on health among European citizens well beyond 2012.

Field of science

  • /medical and health sciences/basic medicine/immunology

Call for proposal

FP7-KBBE-2007-2A
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

KAROLINSKA INSTITUTET
Address
Nobels Vag 5
17177 Stockholm
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 202 896
Administrative Contact
åsa Edström (Ms.)

Participants (22)

INSTITUT PASTEUR
France
EU contribution
€ 494 932
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Activity type
Research Organisations
Administrative Contact
Nadia Khelef (Dr.)
QUEEN MARY UNIVERSITY OF LONDON
United Kingdom
EU contribution
€ 261 216
Address
327 Mile End Road
E1 4NS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tanya Szendeffy (Ms.)
TEKNOLOGIAN TUTKIMUSKESKUS VTT
Finland
EU contribution
€ 628 426
Address
Tekniikantie 4 A
02044 VTT Espoo
Activity type
Research Organisations
Administrative Contact
Katri Kurvinen (Ms.)
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 65 304
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tiina Berg (Ms.)
VARSINAIS-SUOMEN SAIRAANHOITOPIIRIN KUNTAYHTYMA
Finland
EU contribution
€ 65 304
Address
Kiinamyllynkatu 4-8
20520 Turku
Activity type
Research Organisations
Administrative Contact
Risto Laalo (Mr.)
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 261 216
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Margareta Ahlqwist (Dr.)
UNIVERSITE DE LAUSANNE
Switzerland
EU contribution
€ 554 932
Address
Quartier Unil-centre Bâtiment Unicentre
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Walter Wahli (Prof.)
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Netherlands
EU contribution
€ 261 216
Address
Kloveniersburgwal 29 Het Trippenhuis
1011 JV Amsterdam
Activity type
Other
Administrative Contact
Don Van Velzen (Mr.)
UMEA UNIVERSITET
Sweden
EU contribution
€ 351 216
Address
Universitetomradet
901 87 Umea
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anna Nordström (Ms.)
REGION HOVEDSTADEN
Denmark
EU contribution
€ 196 416
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Kate Livemore (Ms.)
DEBRECENI EGYETEM
Hungary
EU contribution
€ 261 216
Address
Egyetem Ter 1
4032 Debrecen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Aniko Kiss (Ms.)
DEUTSCHES INSTITUT FUER ERNAEHRUNGSFORSCHUNG POTSDAM REHBRUECKE
Germany
EU contribution
€ 211 216
Address
Arthur-scheunert-allee 114-116
14558 Nuthetal
Activity type
Research Organisations
Administrative Contact
Judith Schaefer (Dr.)
QUADRAM INSTITUTE BIOSCIENCE
United Kingdom
EU contribution
€ 523 039
Address
Quadram Institute Bioscience Norwich Research Park
NR4 7UQ Norwich
Activity type
Research Organisations
Administrative Contact
Mary Anderson (Dr.)
OY FOODFILES LTD
Finland
EU contribution
€ 16 452
Address
Neulaniementie 2 L 6
70210 Kuopio
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Essi Sarkkinen (Dr.)
STORKBIO
Estonia
EU contribution
€ 43 536
Address
Laki 25
12915 Tallinn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Kristi Kurg (Ms.)
CYCLOLAB CIKLODEXTRIN KUTATO-FEJLES
Hungary
EU contribution
€ 32 736
Address
Illatos 7
1097 Budapest
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Erzsebet Szilagyi (Dr.)
Scandinavian Clinical Nutrition i Sverige AB
Sweden
EU contribution
€ 43 536
Address
Holländargatan 27
113 59 Stockholm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Henrik Andersson (Mr.)
SOREDAB SAS
France
EU contribution
€ 65 808
Address
Lieu Dit La Tremblaye
78125 La Boissiere Ecole
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michel Foucher (Mr.)
ARLA FOODS AMBA
Denmark
EU contribution
€ 65 808
Address
Sonderhoj 14
8260 Viby J
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Robert Svanberg (Mr.)
OLA AND MARTIN STEINBERG HOLDING AB
Sweden
EU contribution
€ 100 000
Address
Topeliusvaegen 3
16761 Bromma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Martin Steinberg (Mr.)
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 189 180
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Hans Demmelmair (Dr.)
INBIO OU

Participation ended

Estonia
Address
Akadeemia Tee 15
12618 Tallinn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Harri Peiker (Mr.)