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The development of tools and effective strategies for the optimisation of useful secondary METAbolite PROduction in planta

Ziel

In the METAPRO project we aim to optimise the production of several useful isoprenoid derived secondary metabolites to demonstrate the tools and strategies developed for the generic production of useful secondary metabolites in plants. Astaxanthin (ketocarotenoids) and the apocarotenoid crocin have been selected to demonstrate the application of the technologies adopted and developed. These compounds are of high-value and used in the industrial and health sectors. Both are classical secondary plant metabolites being formed in slow growing species that are not readily amenable to agricultural production. They are non-essential to the plant, synthesised at a defined developmental stage, in specialised tissues, cells and/or cellular compartments. In order to generate cheap renewable bio-resources of these compounds with improved economic and environmental potential, natural variation will be exploited and genetic engineering approaches implemented. Astaxanthin and crocin will be engineered into Solanaceae host platforms. Tomato fruit and potato tuber are ideal cell factories for this class of molecules, as at defined developmental stages their tissues and specialised cellular compartments are pre-disposed to high level isoprenoid formation. To optimise production in these hosts the METAPRO project aims to use modern and emerging technologies to (i) elucidate regulatory mechanisms involved in synthesis, (ii) optimise storage by increasing, altering and transport from, the cellular compartment responsible for synthesis and accumulation, (iii) improve stability of the products in the cell and during bioprocessing and (iv) implement improved transformation, transcription and translation tools for more efficient engineering and improved yields and quality. To achieve these objectives and deliver scientific excellence with impact a multidisciplinary pan-European team with complementary expertise, industrial (SME) participation and global interaction has been constructed.

Aufforderung zur Vorschlagseinreichung

FP7-KBBE-2009-3
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

CP-FP - Small or medium-scale focused research project

Koordinator

ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE
Adresse
Egham Hill University Of London
TW20 0EX Egham
United Kingdom
Aktivitätstyp
Higher or Secondary Education Establishments
EU-Beitrag
€ 531 935
Kontakt Verwaltung
Paul Fraser (Dr.)

Beteiligte (9)

METAPONTUM AGROBIOS S.R.L.

Beteiligung beendet

Italien
EU-Beitrag
€ 325 440
Adresse
Strada Statale Ionica 106 Km. 448,2 - Frazione Di Metaponto Snc
75012 Bernalda (Mt)
Aktivitätstyp
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Kontakt Verwaltung
Angelo Dichio (Dr.)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Deutschland
EU-Beitrag
€ 484 000
Adresse
Hofgartenstrasse 8
80539 Muenchen
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Beatrice Riedel (Ms.)
AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE
Italien
EU-Beitrag
€ 332 000
Adresse
Lungotevere Grande Ammiraglio Thaon Di Revel 76
000196 Roma
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Giovanni Giuliano (Prof.)
SCOTTISH CROP RESEARCH INSTITUTE
United Kingdom
EU-Beitrag
€ 373 604
Adresse
Invergowrie
DD2 5DA Dundee
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Mark Taylor (Dr.)
THE HEBREW UNIVERSITY OF JERUSALEM
Israel
EU-Beitrag
€ 329 920
Adresse
Edmond J Safra Campus Givat Ram
91904 Jerusalem
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Jane Turner (Ms.)
ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Deutschland
EU-Beitrag
€ 394 650
Adresse
Fahnenbergplatz
79098 Freiburg
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Peter Beyer (Prof.)
AGENZIA LUCANA DI SVILUPPO E DI INNOVAZIONE IN AGRICOLTURA
Italien
Adresse
Via Annunziatella 64
75100 Matera
Aktivitätstyp
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Kontakt Verwaltung
Rosanna Caragiulo (Dr.)
PROPLANTA SRL
Rumänien
EU-Beitrag
€ 209 920
Adresse
Str Ioan Budai Deleanu 28
400474 Cluj Napoca
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Mihai Socaciu (Dr.)
THE JAMES HUTTON INSTITUTE
United Kingdom
Adresse
Errol Road Invergowrie
DD2 5DA Dundee
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Karen Robb (Ms.)