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The development of tools and effective strategies for the optimisation of useful secondary METAbolite PROduction in planta

The development of tools and effective strategies for the optimisation of useful secondary METAbolite PROduction in planta

Objective

In the METAPRO project we aim to optimise the production of several useful isoprenoid derived secondary metabolites to demonstrate the tools and strategies developed for the generic production of useful secondary metabolites in plants. Astaxanthin (ketocarotenoids) and the apocarotenoid crocin have been selected to demonstrate the application of the technologies adopted and developed. These compounds are of high-value and used in the industrial and health sectors. Both are classical secondary plant metabolites being formed in slow growing species that are not readily amenable to agricultural production. They are non-essential to the plant, synthesised at a defined developmental stage, in specialised tissues, cells and/or cellular compartments. In order to generate cheap renewable bio-resources of these compounds with improved economic and environmental potential, natural variation will be exploited and genetic engineering approaches implemented. Astaxanthin and crocin will be engineered into Solanaceae host platforms. Tomato fruit and potato tuber are ideal cell factories for this class of molecules, as at defined developmental stages their tissues and specialised cellular compartments are pre-disposed to high level isoprenoid formation. To optimise production in these hosts the METAPRO project aims to use modern and emerging technologies to (i) elucidate regulatory mechanisms involved in synthesis, (ii) optimise storage by increasing, altering and transport from, the cellular compartment responsible for synthesis and accumulation, (iii) improve stability of the products in the cell and during bioprocessing and (iv) implement improved transformation, transcription and translation tools for more efficient engineering and improved yields and quality. To achieve these objectives and deliver scientific excellence with impact a multidisciplinary pan-European team with complementary expertise, industrial (SME) participation and global interaction has been constructed.
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Coordinator

ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE

Address

Egham Hill University Of London
Tw20 0ex Egham

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 531 935

Administrative Contact

Paul Fraser (Dr.)

Participants (9)

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METAPONTUM AGROBIOS S.R.L.

Italy

EU Contribution

€ 325 440

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

EU Contribution

€ 484 000

AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE

Italy

EU Contribution

€ 332 000

SCOTTISH CROP RESEARCH INSTITUTE

United Kingdom

EU Contribution

€ 373 604

THE HEBREW UNIVERSITY OF JERUSALEM

Israel

EU Contribution

€ 329 920

ALBERT-LUDWIGS-UNIVERSITAET FREIBURG

Germany

EU Contribution

€ 394 650

AGENZIA LUCANA DI SVILUPPO E DI INNOVAZIONE IN AGRICOLTURA

Italy

PROPLANTA SRL

Romania

EU Contribution

€ 209 920

THE JAMES HUTTON INSTITUTE

United Kingdom

Project information

Grant agreement ID: 244348

Status

Closed project

  • Start date

    1 December 2009

  • End date

    31 May 2013

Funded under:

FP7-KBBE

  • Overall budget:

    € 4 137 742

  • EU contribution

    € 2 981 469

Coordinated by:

ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE

United Kingdom

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