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The development of tools and effective strategies for the optimisation of useful secondary METAbolite PROduction in planta

Objective

In the METAPRO project we aim to optimise the production of several useful isoprenoid derived secondary metabolites to demonstrate the tools and strategies developed for the generic production of useful secondary metabolites in plants. Astaxanthin (ketocarotenoids) and the apocarotenoid crocin have been selected to demonstrate the application of the technologies adopted and developed. These compounds are of high-value and used in the industrial and health sectors. Both are classical secondary plant metabolites being formed in slow growing species that are not readily amenable to agricultural production. They are non-essential to the plant, synthesised at a defined developmental stage, in specialised tissues, cells and/or cellular compartments. In order to generate cheap renewable bio-resources of these compounds with improved economic and environmental potential, natural variation will be exploited and genetic engineering approaches implemented. Astaxanthin and crocin will be engineered into Solanaceae host platforms. Tomato fruit and potato tuber are ideal cell factories for this class of molecules, as at defined developmental stages their tissues and specialised cellular compartments are pre-disposed to high level isoprenoid formation. To optimise production in these hosts the METAPRO project aims to use modern and emerging technologies to (i) elucidate regulatory mechanisms involved in synthesis, (ii) optimise storage by increasing, altering and transport from, the cellular compartment responsible for synthesis and accumulation, (iii) improve stability of the products in the cell and during bioprocessing and (iv) implement improved transformation, transcription and translation tools for more efficient engineering and improved yields and quality. To achieve these objectives and deliver scientific excellence with impact a multidisciplinary pan-European team with complementary expertise, industrial (SME) participation and global interaction has been constructed.

Call for proposal

FP7-KBBE-2009-3
See other projects for this call

Coordinator

ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE
Address
Egham Hill University Of London
TW20 0EX Egham
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 531 935
Administrative Contact
Paul Fraser (Dr.)

Participants (9)

METAPONTUM AGROBIOS S.R.L.

Participation ended

Italy
EU contribution
€ 325 440
Address
Strada Statale Ionica 106 Km. 448,2 - Frazione Di Metaponto Snc
75012 Bernalda (Mt)
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Angelo Dichio (Dr.)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 484 000
Address
Hofgartenstrasse 8
80539 Munchen
Activity type
Research Organisations
Administrative Contact
Beatrice Riedel (Ms.)
AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE
Italy
EU contribution
€ 332 000
Address
Lungotevere Grande Ammiraglio Thaon Di Revel 76
00196 Roma
Activity type
Research Organisations
Administrative Contact
Giovanni Giuliano (Prof.)
SCOTTISH CROP RESEARCH INSTITUTE
United Kingdom
EU contribution
€ 373 604
Address
Invergowrie
DD2 5DA Dundee
Activity type
Research Organisations
Administrative Contact
Mark Taylor (Dr.)
THE HEBREW UNIVERSITY OF JERUSALEM
Israel
EU contribution
€ 329 920
Address
Edmond J Safra Campus Givat Ram
91904 Jerusalem
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jane Turner (Ms.)
ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Germany
EU contribution
€ 394 650
Address
Fahnenbergplatz
79098 Freiburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peter Beyer (Prof.)
AGENZIA LUCANA DI SVILUPPO E DI INNOVAZIONE IN AGRICOLTURA
Italy
Address
Via Annunziatella 64
75100 Matera
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Rosanna Caragiulo (Dr.)
PROPLANTA SRL
Romania
EU contribution
€ 209 920
Address
Str Ioan Budai Deleanu 28
400474 Cluj Napoca
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Mihai Socaciu (Dr.)
THE JAMES HUTTON INSTITUTE
United Kingdom
Address
Errol Road Invergowrie
DD2 5DA Dundee
Activity type
Research Organisations
Administrative Contact
Karen Robb (Ms.)