CORDIS
EU research results

CORDIS

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Genomic variations underlying common behavior diseases and cognition trait in human populations

Project information

Grant agreement ID: 242257

Status

Closed project

  • Start date

    1 October 2009

  • End date

    30 September 2012

Funded under:

FP7-HEALTH

  • Overall budget:

    € 5 678 333,60

  • EU contribution

    € 3 000 000

Coordinated by:

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

Objective

The subject of the proposal is the search and analysis of genomic variations underlying Alzheimer's disease (AD), alcoholism and schizophrenia – wide-spread diseases in human populations. Schizophrenia and alcoholism are common forms of behavior pathology and disability in adult life. AD is a most common form of dementia in human populations. Though the genomic variations presumably associated with AD, alcoholism and schizophrenia were described in preliminary studies for European populations, the significance of the putatively associated alleles, genetic background as well as the role of environmental factors is still poorly understood for them. Within the framework of this project we plan to extend the studies of genomic variations underlying these diseases by performing genome-wide association analysis in cohorts of patients and normal individuals from several ethnic populations of Europe and Russia.The genetic factors for cognition endophenotype will also be studied. Candidate regions, both newly found and reported previously for these diseases will be additionally analyzed by sequencing. Such large scale population studies combined with deep analysis of particular genes and genomic regions will allow us to reveal genetic reasons for susceptibility to these diseases. On the basis of this research we propose to contribute to development of a diagnostic instrument for the analysis of genetic risk factors for AD, alcoholism and schizophrenia. Comparison of several ethnic cohorts (different populations from Russia and Central/Western and Southern Europe) will also help to elucidate the influence of genetic background and environmental factors on the etiology of neuropsychiatric diseases. Consortium includes 6 groups from EU/AC and 7 groups from Russia. The participants are leading specialists in their fields and have joint publications on subjects related to this proposal.

Coordinator

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Address

Hofgartenstrasse 8
80539 Munich

Germany

Activity type

Other

EU Contribution

€ 618 000

Administrative Contact

Joachim Gerlach (Mr.)

Participants (11)

UNIVERSITAT BASEL

Switzerland

EU Contribution

€ 783 000

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands

EU Contribution

€ 378 000

KING'S COLLEGE LONDON

United Kingdom

EU Contribution

€ 435 000

ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT

Germany

EU Contribution

€ 393 000

UNIVERSITATSKLINIKUM BONN

Germany

EU Contribution

€ 393 000

ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY OF RUSSIAN ACADEMY

Russia

Vavilov Institute of General Genetics - Russian Academy of Sciences

Russia

NATIONAL RESEARCH CENTER OF MENTAL HEALTH - RUSSIAN ACADEMY OF MEDICAL SCIENCES

Russia

INSTITUTE OF BIOCHEMISTRY AND GENETICS, UFA SCIENTIFIC CENTRE OF RAS

Russia

NII MEDICINSKOY GENETIKI TOMSKOGO NAUCHNOGO CENTRA SIBIRSKOGO OTDELENIYA ROSSIYSKOY AKADEMII MEDICINSKIH NAUK

Russia

University Medicine OOO

Russia

Project information

Grant agreement ID: 242257

Status

Closed project

  • Start date

    1 October 2009

  • End date

    30 September 2012

Funded under:

FP7-HEALTH

  • Overall budget:

    € 5 678 333,60

  • EU contribution

    € 3 000 000

Coordinated by:

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany