Objective
With 14.4 million prevalent cases and 1.7 million deaths tuberculosis (TB) remains one of the most serious infectious diseases to date. An estimated 2 billion people are believed to be infected with Mycobacterium tuberculosis and at risk of developing disease. Multi- and extensively drug resistant strains are increasingly appearing in many parts of the world, including Europe. While with current control measures the Millennium Development Goals (MDGs) set for 2015 may be achieved, reaching these would still leave a million people per year dying from TB. Much more effective measures, particularly more effective vaccines will be essential to reach the target of eliminating TB in 2050. Two successive FP5 and FP6 funded projects, Tuberculosis (TB) Vaccine Cluster (2000-2003) and TBVAC (2004-2008), have in the recent decade made significant contributions to the global TB vaccine pipeline, with four vaccines (out of nine globally) being advanced to clinical stages. Both projects strongly contributed to the strengthening and integration of expertise and led to a European focus of excellence that is unique in the area of TB vaccine development. In order to sustain and accelerate the TB vaccine developments and unique integrated excellence of TBVAC, a specific legal entity was created named TuBerculosis Vaccine Initiative (TBVI). The NEWTBVAC proposal is the FP7 successor of TBVAC, and will be coordinated by TBVI. The proposal has the following objectives : 1) To sustain and innovate the current European pipeline with new vaccine discoveries and advance promising candidates to clinical stages; 2) To design new, second generation vaccines based new prime-boost strategies and/or new (combinations of) promising subunit vaccines, that will impact on reduction of disease in exposed individuals; 3) To sustain and innovate discovery, evaluation and testing of new biomarkers, that will be critically important for future monitoring of clinical trials.
Fields of science
Call for proposal
FP7-HEALTH-2009-single-stage
See other projects for this call
Funding Scheme
CP-IP - Large-scale integrating projectCoordinator
8219 PH Lelystad
Netherlands
Participants (34)
2300 Kobenhavn S
72074 Tuebingen
89081 Ulm
2333 ZA Leiden
1050 Bruxelles
1330 Rixensart
75794 Paris
4031 Basel
00161 Roma
1211 Geneve
OX1 2JD Oxford
91054 Erlangen
B4 7ET Birmingham
59019 Lille
1050 Bruxelles
75724 Paris Cedex 15
136 791 Seoul
50009 Zaragoza
80539 Muenchen
8006 Zurich
35122 Padova
Participation ended
SE1 8UG London
2288 GJ Rijswijk Zh
120 749 Seoul
151919 Seoul
6708 PB Wageningen
08916 Badalona Barcelona
WC1E 7HT London
90133 Palermo
6500 Bellinzona
38027 Grenoble
2500 EJ Den Haag
30625 Hannover
LS2 7UE Leeds