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CHEMICAL SUBSTANCE IN VITRO/IN SILICO SCREENING SYSTEM TO PREDICT HUMAN- AND ECOTOXICOLOGICAL EFFECTS

CHEMICAL SUBSTANCE IN VITRO/IN SILICO SCREENING SYSTEM TO PREDICT HUMAN- AND ECOTOXICOLOGICAL EFFECTS

Objective

The current system of risk assessment of chemicals is complex, very resource-intensive and extremely time-consuming. Because of this, there is a great need to modernize this process. However, this is not feasible without alternative, integrated testing strategies in which chemical characteristics are used to more advantage and where costly and time consuming animal tests are replaced to a large extent by more rapid, cheap and ethically less controversial methods. This is particularly needed for reproductive toxicity testing of chemicals. Reproductive toxicity is important to assess both human and environmental toxicity and uses the most animals in toxicity testing. Unfortunately, there are very few alternative methods. ChemScreen aims to fill this gap and place the tests in a more general innovative animal-free testing strategy. For this, we will generate a simple rapid screening system, which aims at widespread implementation within the tight time schedule of the REACH program. It will be a flexible tool that can be adapted and used for applications beyond the scope of REACH and in the post-REACH period. It will use in silico methods for prescreening chemicals for all relevant toxic effects. When found positive, this will be followed by further in silico and in vitro tests, most of which are available already. To fill the gap of suitable alternative methods for reproductive toxicity testing we will use a novel high throughput approach combining in silico/in vitro methods. In this approach we will combine knowledge of critical processes affected by reproductive toxicants with knowledge on the mechanistic basis of such effects. Straightforward data interpretation and decision trees will be developed in which all information on the potential toxicity of a chemical is considered. In this way we will provide a cost-effective means to generate a basic set of data on toxicological properties of chemicals and a decision tool to assess if further testing of chemicals is required.

Coordinator

BioDetection Systems B.V.

Address

Science Park 406
1098 Xh Amsterdam

Netherlands

Activity type

Other

EU Contribution

€ 995 904

Administrative Contact

Yvette Van Scheppingen (Ms.)

Participants (9)

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PROCTER & GAMBLE EUROCOR N.V.

Belgium

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

Germany

EU Contribution

€ 266 346

NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO

Netherlands

EU Contribution

€ 400 936

SIMPPLE SLU

Spain

EU Contribution

€ 214 656

RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU

Netherlands

EU Contribution

€ 385 951

DANMARKS TEKNISKE UNIVERSITET

Denmark

EU Contribution

€ 352 975

PROCTER & GAMBLE SERVICES COMPANY NV

Belgium

EU Contribution

€ 286 675

EBERHARD KARLS UNIVERSITAET TUEBINGEN

Germany

EU Contribution

€ 293 680

UNIVERSITAT KONSTANZ

Germany

EU Contribution

€ 299 600

Project information

Grant agreement ID: 244236

Status

Closed project

  • Start date

    1 January 2010

  • End date

    31 December 2013

Funded under:

FP7-ENVIRONMENT

  • Overall budget:

    € 4 609 052

  • EU contribution

    € 3 496 723

Coordinated by:

BioDetection Systems B.V.

Netherlands