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Fatty liver: Inhibition of Progression

Objective

Non-alcoholic fatty liver disease (NAFLD) has become one of the top concerns for the practising hepatogastroenterologist due to the obesity epidemic and its potential to progress to advanced liver disease which significantly impacts on overall and liver-related mortality. The aim of the FLIP (Fatty Liver: Inhibition of Progression) project is to understand and prevent the progression of liver disease in NAFLD. FLIP is a consortium of basic scientists and practising clinical hepatologists with an established track record and focus on research into the underlying mechanisms and management of patients with NAFLD. Therefore FLIP provides a unique opportunity to assemble the largest European cohort of patients with histologically diagnosed NAFLD with clinical and epidemiological data and with biobanks of DNA, frozen liver tissue and serum. These will be used in a wide range of collaborative inter-disciplinary research projects aimed at addressing key unanswered questions related to the mechanisms and consequences of liver injury in NAFLD and the development of novel preventive and therapeutic strategies. The main outcomes of FLIP will be new insights in the progression of liver disease in NAFLD in terms of initiating mechanisms and patients at risk, innovative diagnostic methods particularly adapted for large-scale screening and prognostic evaluation, improved implementation of lifestyle changes, collaboration with leading biotechnological or pharmaceutical companies in order to translate to the market diagnostic tests or newly identified molecular targets for pharmacological therapy. By disseminating the project’s results, FLIP will further help the European Community to suggest guidelines on the management of this emerging liver disease. The long-term goal is to lay the foundations for the future of NAFLD research in Europe by creating a Collaborative Research Network on NAFLD that will continue the work initiated by the FLIP consortium.

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
Address
3 Avenue Victoria
75000 Paris
France
Activity type
Research Organisations
EU contribution
€ 957 876,15
Administrative Contact
Christophe Misse (Mr.)

Participants (16)

Biopredictive
France
EU contribution
€ 361 400
Address
Rue Du Bac 40
75007 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jean-Marie Castille (Mr.)
AYMING
France
EU contribution
€ 229 720
Address
Rue Chaptal 114
92300 Levallois-perret
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Franck Noumbissie (Mr.)
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
EU contribution
€ 1 303 548
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Aleona Blinova (Ms.)
UNIVERSITY OF BRISTOL
United Kingdom
EU contribution
€ 185 776
Address
Beacon House Queens Road
BS8 1QU Bristol
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Vince Boyle (Mr.)
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy
EU contribution
€ 268 100
Address
Via Zamboni 33
40126 Bologna
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Diego Torresan (Dr.)
UNIVERSITA DEGLI STUDI DI FIRENZE
Italy
EU contribution
€ 237 040
Address
Piazza San Marco 4
50121 Florence
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Fabio Marra (Prof.)
UNIVERSITA DEGLI STUDI DI TORINO
Italy
EU contribution
€ 533 597
Address
Via Giuseppe Verdi 8
10124 Torino
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Elisabetta Bugianesi (Dr.)
UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA
Italy
EU contribution
€ 185 594
Address
Via Universita 4
41121 Modena
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paola Borella (Prof.)
MEDIZINISCHE UNIVERSITAT GRAZ

Participation ended

Austria
Address
Auenbruggerplatz 2
8036 Graz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michael Trauner (Prof.)
UNIVERSITAET BERN
Switzerland
EU contribution
€ 348 234
Address
Hochschulstrasse 6
3012 Bern
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jean-François Dufour (Prof.)
SERVICIO ANDALUZ DE SALUD
Spain
EU contribution
€ 230 200
Address
Avenida De La Constitucion 18
41071 Sevilla
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Manuel Romero-Gómez (Dr.)
REGION HOVEDSTADEN
Denmark
EU contribution
€ 349 873
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Kate Livemore (Ms.)
ASTELLAS PHARMA EUROPE BV

Participation ended

Netherlands
EU contribution
€ 35 602,85
Address
Sylviusweg 84
2333 BE Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Steve Van Os (Dr.)
FONDAZIONE ITALIANA FEGATO ONLUS
Italy
EU contribution
€ 209 520
Address
Area Science Park, Bldg Q, Ss14, Km 163.5
34012 Trieste
Activity type
Research Organisations
Administrative Contact
Sabrina Corsucci (Ms.)
UNIVERSITA POLITECNICA DELLE MARCHE
Italy
EU contribution
€ 207 240
Address
Piazza Roma 22
60121 Ancona
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gianluca Svegliati Baroni (Dr.)
MEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 340 156,80
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Josef Smolen