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INtegrated HEart Research In TrANslational genetics of dilated Cardiomyopathies in Europe

Objective

Inherited dilated cardiomyopathies (DCM) are monogenic disorders caused by mutations in more than 30 genes, characterised by substantial phenotype heterogeneity. DCM affects 1:2.500 individuals and is the major cause of heart transplantation and death for non-ischaemic heart failure in adolescents and young adults. Currently, less than 1% of patients with familial DCM are genotyped in Europe. The INHERITANCE (INtegrated HEart Research In TrANslational genetics of dilated Cardiomyopathies in Europe) consortium propose to investigate over 2,000 existing DCM patients and their relatives in order to translate novel insights on the aetiology and pathophysiology of inherited cardiomyopathies into innovative disease specific diagnostic and treatment strategies. The consortium members share common clinical, scientific and ethical standards with respect to patient care and family screening, and have individual expertise in the clinical management and molecular genetics of inherited cardiomyopathies. The INHERITANCE strategy is to integrate genomic, proteomic, structural and functional studies exploring the molecular cascades arising from causative mutations with innovative clinical assessments in order to understand disease expression, evolution and to explore novel therapeutic strategies both in humans and in animal models. The immediate benefits will include preclinical and presymptomatic diagnosis, family-tailored clinical work-up, optimisation of existing treatment strategies and cost-effective use of medical resources. In the medium term, these studies will catalyse the development of new disease specific protocols, and will provide a model for the exploration of ground-breaking genetic and pharmacological therapies.

Field of science

  • /natural sciences/biological sciences/molecular biology/molecular genetics
  • /natural sciences/biological sciences/genetics and heredity/mutation

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

FONDAZIONE IRCCS POLICLINICO SAN MATTEO
Address
Viale Golgi 19
27100 Pavia
Italy
Activity type
Research Organisations
EU contribution
€ 573 127
Administrative Contact
Franco Marazza (Dr.)

Participants (10)

University College London
United Kingdom
EU contribution
€ 200 672
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms.)
REGION VASTERBOTTEN
Sweden
EU contribution
€ 71 700
Address
Koksvagen 11
901 89 Umea
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Simon Lindgren (Mr.)
UNIVERSITATSKLINIKUM HEIDELBERG
Germany
EU contribution
€ 445 808
Address
Im Neuenheimer Feld 672
69120 Heidelberg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thorsten Brietz
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 330 040
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Isabelle Verdier (Ms.)
Health in Code SL
Spain
EU contribution
€ 246 660
Address
Ed. Fortin. Hospial Marítimo De Oza. As Xubias
15006 A Coruna
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Lorenzo Monserrat (Dr.)
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 236 755
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Damien Briggs (Mr.)
AARHUS UNIVERSITETSHOSPITAL, SKEJBY
Denmark
EU contribution
€ 168 416
Address
Brendstrupgaardsvej 100
8200 Aarhus N
Activity type
Research Organisations
Administrative Contact
Jens Mogensen (Dr.)
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 209 310
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lieve Peeters (Ms.)
UNIVERSITA DEGLI STUDI DI PAVIA
Italy
EU contribution
€ 184 095
Address
Strada Nuova 65
27100 Pavia
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Riccardo Bellazzi (Prof.)
UNIVERSITA DEGLI STUDI DI MILANO
Italy
EU contribution
€ 204 208
Address
Via Festa Del Perdono 7
20122 Milano
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stefania Varotto (Dr.)