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Combined Highly Active Anti-retroviral Microbicides

Combined Highly Active Anti-retroviral Microbicides

Objective

This proposal is for a large scale collaborative project in which we propose both to develop novel microbicides directed against new intracellular targets and to investigate novel combinations of highly active anti-retroviral drugs which may be particularly effective as microbicides. Combinations may enhance efficacy but equally importantly will increase the genetic barrier to the development of resistance. The proposal includes development of both slow release and gel formulations, pharmacokinetic and challenge experiments in macaques as well as human studies including a collaborative study with an EDCTP-funded project to use multiplex and proteomic technologies as well as culture-independent DNA-based analysis of mucosal microbiota to investigate biomarkers and establish a baseline signature from which perturbations can be recognised. This is a large consortium comprising 30 partners from 8 EU countries and from Switzerland, Ukraine, South Africa and the United States.Partners include microbicide developers, IPM and Particle Sciences, and producers, Gilead, Tibotec and Virco. Two SMEs will also participate in RTD aspects. The consortium is multidisciplinary with scientists engaged in basic discovery working with new targets and developing novel chemistry to produce compounds with improved safety and efficacy profiles as well as altered patterns of resistance.

Coordinator

KING'S COLLEGE LONDON

Address

Strand
Wc2r 2ls London

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 203 352,85

Administrative Contact

Paul Labbett (Mr.)

Participants (33)

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ST GEORGE'S HOSPITAL MEDICAL SCHOOL

United Kingdom

EU Contribution

€ 432 200,45

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

EU Contribution

€ 1 867 938,76

PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE

Belgium

EU Contribution

€ 694 000,40

UNIVERSITEIT ANTWERPEN

Belgium

EU Contribution

€ 336 000

THE QUEEN'S UNIVERSITY OF BELFAST

United Kingdom

EU Contribution

€ 299 854

UNIVERSITAT BASEL

Switzerland

EU Contribution

€ 305 000

UNIVERSITA DEGLI STUDI DI SIENA

Italy

EU Contribution

€ 399 679

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

EU Contribution

€ 899 000

UNIVERSITY COLLEGE LONDON

United Kingdom

EU Contribution

€ 203 896,80

Fondazione Centro San Raffaele

Italy

EU Contribution

€ 231 548

UNIVERSITY OF YORK

United Kingdom

EU Contribution

€ 460 689,01

UNIVERSITEIT UTRECHT

Netherlands

EU Contribution

€ 299 000

INSTITUTO DE SALUD CARLOS III

Spain

EU Contribution

€ 300 000

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE

Spain

EU Contribution

€ 299 000

COUNCIL FOR SCIENTIFIC AND INDUSTRIAL RESEARCH

South Africa

EU Contribution

€ 296 568

UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA

Italy

EU Contribution

€ 298 920

Spoluka Chemical Company Ltd

Ukraine

EU Contribution

€ 299 000

MINERVA CONSULTING & COMMUNICATION

Belgium

EU Contribution

€ 200 560

STICHTING AMSTERDAM INSTITUTE FOR GLOBAL HEALTH AND DEVELOPMENT

Netherlands

EU Contribution

€ 58 048,90

POLYMUN SCIENTIFIC IMMUNBIOLOGISCHE FORSCHUNG GMBH

Austria

EU Contribution

€ 109 000

GILEAD SCIENCES INC

United States

Particle Sciences Inc.

United States

EU Contribution

€ 503 000

UNIVERSITE DE GENEVE

Switzerland

EU Contribution

€ 299 000

International Partnership for Microbicides, INC

United States

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 296 360

EUROPEAN AIDS TREATMENT GROUP EV

Germany

EU Contribution

€ 33 000

Fondation Mintaka pour la Recherche Médicale

Switzerland

JANSSEN INFECTIOUS DISEASES DIAGNOSTICS BVBA

Belgium

EU Contribution

€ 50 000

MICROBIOTEC SRL

Italy

EU Contribution

€ 198 000

MIDDLESEX UNIVERSITY HIGHER EDUCATION CORPORATION

United Kingdom

EU Contribution

€ 300 000

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

EU Contribution

€ 417 799,54

THE UNIVERSITY OF LIVERPOOL

United Kingdom

EU Contribution

€ 41 950,69

Fondazione Centro San Raffaele

Italy

EU Contribution

€ 367 632

Project information

Grant agreement ID: 242135

Status

Closed project

  • Start date

    1 January 2010

  • End date

    30 June 2015

Funded under:

FP7-HEALTH

  • Overall budget:

    € 17 067 499,59

  • EU contribution

    € 11 999 998,40

Coordinated by:

KING'S COLLEGE LONDON

United Kingdom