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European Consortium on Synaptic Protein Networks in Neurological and Psychiatric Diseases

Objective

Signalling at nerve cell synapses - a key determinant of all aspects of brain function - depends on the function of hundreds of synaptic proteins and their interactions. Numerous recent studies showed that a wide range of neurological and psychiatric diseases are 'synaptopathies' whose onset and progression are due to mutations of synaptic proteins and subsequent synaptic dysfunctions. EUROSPIN will pursue a multilevel systems biology approach to determine mechanistic relationships between mutations of synaptic proteins and neurological and psychiatric diseases, and to develop new diagnostic tools and therapies. Our concept is based on the current knowledge of disease genes, which we will continuously extend with new human genetic data and complement with large-scale screens of mutant mice in order to identify and characterize disease-relevant mutations in synaptic proteins and corresponding mouse models. Proteomic tools will be used to analyse the protein components of synapses, and protein interaction networks of synaptic disease gene products will be mapped systematically. In parallel, smart libraries will be employed to develop small molecules for perturbing the functions and interactions of disease gene products. Functional models of disease-relevant protein networks will be generated and used to formulate hypotheses as to how specific mutations might affect synaptic physiology and network function, and thus cause disease. These hypotheses will initially be tested in reduced systems by novel physiological and imaging methods. Well-validated disease gene products, the consequences of their dysfunction in disease, and therapeutic modifications of their dysfunction will then be studied in mouse models in vivo, applying novel electrophysiological, imaging, and behavioural techniques. The combined information obtained in the EUROSPIN program will be used for the development of new diagnostic tools and therapeutic interventions that can be tested in patients.

Call for proposal

FP7-HEALTH-2009-single-stage
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Coordinator

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Address
Hofgartenstrasse 8
80539 Munchen
Germany

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Activity type
Research Organisations
Administrative Contact
Nils Brose (Prof.)
EU contribution
€ 2 845 290

Participants (17)

VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG

Participation ended

Netherlands
Address
De Boelelaan 1105
1081 HV Amsterdam

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Els Borghols (Ms.)
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel
EU contribution
€ 301 440
Address
Senate Building Technion City
32000 Haifa

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jacob Lavan (Mr.)
MEDICAL RESEARCH COUNCIL

Participation ended

United Kingdom
EU contribution
€ 206 133,50
Address
20 Park Crescent
W1B 1AL London

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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Claire Hebblethwaite (Ms.)
GENOME RESEARCH LIMITED

Participation ended

United Kingdom
EU contribution
€ 452 922,52
Address
The Gibbs Building, Euston Road 215
NW1 2BE London

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Activity type
Research Organisations
Administrative Contact
David N Davison (Mr.)
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
Germany
EU contribution
€ 692 034
Address
Robert Rossle Strasse 10
13125 Berlin

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Activity type
Research Organisations
Administrative Contact
Flügge Tanja (Ms.)
UNIVERSITA DEGLI STUDI DI MILANO
Italy
EU contribution
€ 478 200
Address
Via Festa Del Perdono 7
20122 Milano

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Federica Tidone (Dr.)
UNIVERSITY COLLEGE LONDON
United Kingdom
EU contribution
€ 580 307
Address
Gower Street
WC1E 6BT London

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms.)
UNIVERSITY OF HAIFA
Israel
EU contribution
€ 554 748
Address
Abba Khushy Blvd Mount Carmel
31905 Haifa

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Suzan Aminpour (Ms.)
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 1 948 514,48
Address
Old College, South Bridge
EH8 9YL Edinburgh

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Angela Noble (Ms.)
UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 575 200
Address
Ramistrasse 71
8006 Zurich

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
David P. Wolfer (Prof.)
Novartis Forschungsstiftung

Participation ended

Switzerland
Address
Maulbeerstrasse 66
4058 Basel

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Activity type
Research Organisations
Administrative Contact
Dorothy Searles (Ms.)
Synaptic Systems
Germany
EU contribution
€ 562 987
Address
Rudolf-wissell Straße 28
37079 Göttingen

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jutta Kuester (Dr.)
SYNAPTOLOGICS BV
Netherlands
EU contribution
€ 988 425
Address
Achillesstraat 28 2
1008 BA Amsterdam

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Evelyn Van Royen (Mrs.)
Synome Ltd
United Kingdom
EU contribution
€ 325 993
Address
Moneta Building Babraham Research Campus
CB4 1GU Cambridge

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Troels Jordansen (Mr.)
RIKEN THE INSTITUTE OF PHYSICAL ANDCHEMICAL RESEARCH
Japan
EU contribution
€ 236 735,50
Address
Hirosawa 2-1
351 0198 Wako Shi Saitama

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Activity type
Research Organisations
Administrative Contact
Haruo Yamaguchi (Mr.)
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
Switzerland
EU contribution
€ 616 439
Address
Maulbeerstrasse 66
4058 Basel

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Activity type
Research Organisations
Administrative Contact
Dorothy Searles (Ms.)
STICHTING VU
Netherlands
EU contribution
€ 587 322
Address
De Boelelaan 1105
1081 HV Amsterdam

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Yvonne Kops (Dr.)