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Construction kit for tailor-made vascularized boneimplants

Objectif

The goal of VascuBone is to develop a “tool box” for bone regeneration, which on one hand fulfils basic requirements and on the other hand is freely combinable with what is needed in the respective patient’s situation. The tool box will include a variation of biocompatible biomaterials and cell types, FDA approved growth factors, material modification technologies, simulation and analytical tools like molecular imaging based in vivo diagnostics which can be combined for the specific medical need. This tool box will be used to develop translational approaches for regenerative therapies of three different types of bone defects. The chosen bone diseases differ in their requirements, to ensure a successful implementation and translation. Additionally this implementation strategy is characterized by high complexity to remove bottlenecks and limitations of bone regeneration identified in the clinical setting. Therefore definite quality criteria have to be evaluated concerning an optimal stem cell source/subpopulation as well as GF concentrations and their bioactivity in vivo. Furthermore quantitative evaluation will focus on the definition of differences between stem cell populations responsible for bone regeneration in young and old people, as a prerequisite for the development of regenerative therapies for the ageing European society. Considering a successful and prompt approval of the biomaterial, for each clinical application a minimum of modification steps in daily routine must be identified. The road map of the project and clinic trials contains pre-determined milestones, to ensure efficacy, safety, and immunological acceptance of the implant. The efficacy is quantified by high innovative MRI and PET/CT technology which is able to demonstrate the regenerative effect of biomaterials and cells in vivo. Based on the clinical data the proposal as “Advanced Therapeutical Medicinal Product” will be submitted to the European Medicines Agency at the end of the project.

Appel à propositions

FP7-HEALTH-2009-single-stage
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Coordinateur

FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Adresse
Hansastrasse 27C
80686 Munchen
Allemagne
Type d’activité
Research Organisations
Contribution de l’UE
€ 2 380 655,59
Contact administratif
Christoph Schulte (Mr.)

Participants (17)

KUNGLIGA TEKNISKA HOEGSKOLAN
Suède
Contribution de l’UE
€ 597 280
Adresse
Brinellvagen 8
100 44 Stockholm
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Maria Andersz (Ms.)
KOMET RHOBEST GMBH

Participation terminée

Autriche
Contribution de l’UE
€ 367 981
Adresse
Exlgasse 20A
6020 Innsbruck
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Doris Steinmüller-Nethl (Dr.)
UPPSALA UNIVERSITET
Suède
Contribution de l’UE
€ 357 680
Adresse
Von Kraemers Alle 4
751 05 Uppsala
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Karin Larsson (Prof.)
JOHNSON & JOHNSON MEDICAL GMBH

Participation terminée

Allemagne
Contribution de l’UE
€ 129 883
Adresse
Robert Koch Strasse 1
22851 Norderstedt
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Juergen Trzewik (Dr.)
UNIVERSITETET I BERGEN
Norvège
Contribution de l’UE
€ 1 082 480
Adresse
Museplassen 1
5020 Bergen
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Inger Gjesdahl (Ms.)
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
Allemagne
Contribution de l’UE
€ 1 816 592
Adresse
Sanderring 2
97070 Wuerzburg
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Christian Gloggengiesser (Mr.)
OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN
Autriche
Contribution de l’UE
€ 327 667,86
Adresse
Dr. Ignaz Seipel-platz 2
1010 Wien
Type d’activité
Research Organisations
Contact administratif
Günter Lepperdinger (Dr.)
CellTech Services Götz GmbH

Participation terminée

Allemagne
Contribution de l’UE
€ 51 903,41
Adresse
Uhlandstr. 16
63500 Seligenstadt
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Alexander Goetz (Dr.)
MEDIZINISCHE UNIVERSITAT INNSBRUCK
Autriche
Contribution de l’UE
€ 1 172 180
Adresse
Christoph Probst Platz 1
6020 Innsbruck
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Frank Kloss (Prof.)
MRB Forschungszentrum fur Magnet-Resonanz-Bayern e.V.
Allemagne
Contribution de l’UE
€ 898 500
Adresse
Am Hubland
97074 Wuerzburg
Type d’activité
Research Organisations
Contact administratif
Karl-Heinz Hiller (Dr.)
NANOPET PHARMA GMBH
Allemagne
Contribution de l’UE
€ 528 156
Adresse
Robert-koch-platz 4
10115 Berlin
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Nicole Gärtner (Ms.)
PP-POLYMER AB
Suède
Contribution de l’UE
€ 431 899
Adresse
Krossgatan 15
162 50 Vallingby
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Ann-Christin Paul (Mrs.)
MEDICYTE GMBH
Allemagne
Contribution de l’UE
€ 742 000
Adresse
Im Neuenheimer Feld 581
69120 Heidelberg
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Stefan Holder
TOPASS GMBH
Allemagne
Contribution de l’UE
€ 364 272
Adresse
Drakestrasse 42
12205 Berlin
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Jutta Vom Brocke (Ms.)
UNIVERSITAET INNSBRUCK
Autriche
Contribution de l’UE
€ 261 757,14
Adresse
Innrain 52
6020 Innsbruck
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Günter Lepperdinger (Dr.)
DIACOATING GMBH
Autriche
Contribution de l’UE
€ 374 926
Adresse
Mitterweg 24
6020 Innsbruck
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Armin Partl (Mr.)
EVONIK INDUSTRIES AG
Allemagne
Contribution de l’UE
€ 80 258
Adresse
Rellinghauser Strasse 1-11
45128 Essen
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Thomas Rode (Mr.)