Objective Osteoarthritis (OA) is a degenerative joint disease for which no efficient therapy is available. The ADIPOA consortium has previously shown that intraarticular injections of stromal cells prevents OA in two different models, but the mechanisms of this chondroprotective effect remains unknown, and the activation of cartilage derived endogenous stem cells is suspected. The participants have experience on cell therapy, logistic and production facilities for adipose derived stromal cells (ASC) and clinical studies focusing on cartilage repair. They have shown that stromal cells have anti-inflammatory and antiapoptosis effets, prevent cells from senescence and protect endogenous cells from oxidative stress. ASC are well described, and the procedure to expand the ASC in GMP clinical grade by one of us has been approved by regulatory authorities. This has prompted us to propose an original and innovative regenerative medicine approach for OA in a four years programme organised around 6 workpackages : · WP 1 ASC biology, cell processing & optimization for chondral protection · WP 2 In vivo validation of chondroprotective effect of ASC · WP 3 Safety, Security & regulatory issues · WP 4 Clinical trial endogenous ASC injected intraarticular in OA · WP 5 Management and Coordination · WP 6 Training and Education ADIPOA project will then lead to the optimisation and standardisation of production procedures. In vivo validation and optimisation shall lead to a phase 1 clinical trial and the design and initiation of a phase 2 controlled study in OA. The ADIPOA Consortium comprises 10 academic and 2 sme participants and gathers researchers and clinicians with expertise in clinical research, chondrocytes and adipose stem cell biology and regenerative medicine. The Sme participation will ensure the dissemination of the project results. The critical mass achieved by the ADIPOA Consortium should enable clinical applications in OA. Fields of science natural sciencesbiological sciencescell biologymedical and health sciencesmedical biotechnologycells technologiesstem cells Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2009-1.4-1 - Cell therapy for tissue and organs HEALTH-2009-1.4-3 - Activation of endogenous cells as an approach to regenerative medicine Call for proposal FP7-HEALTH-2009-single-stage See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator CENTRE HOSPITALIER UNIVERSITAIRE MONTPELLIER EU contribution € 2 167 455,00 Address AVENUE DU DOYEN GASTON GIRAUD 191 34000 Montpellier France See on map Region Occitanie Languedoc-Roussillon Hérault Activity type Research Organisations Administrative Contact Valérie Handweiler (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (11) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITY OF GALWAY Ireland EU contribution € 477 616,00 Address UNIVERSITY ROAD H91 Galway See on map Region Ireland Northern and Western West Activity type Higher or Secondary Education Establishments Administrative Contact Roger Sweetman (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France EU contribution € 548 098,00 Address RUE MICHEL ANGE 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Armelle Barelli (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ISTITUTO ORTOPEDICO RIZZOLI Italy EU contribution € 769 750,00 Address VIA DI BARBIANO 1/10 40136 Bologna See on map Region Nord-Est Emilia-Romagna Bologna Activity type Research Organisations Administrative Contact Andrea Rizzi (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Laboratoires MABIO International France EU contribution € 385 700,00 Address du Pont Rompu 96 59203 Tourcoing See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Dominique Malard (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STICHTING RADBOUD UNIVERSITEIT Netherlands EU contribution € 636 320,00 Address HOUTLAAN 4 6525 XZ Nijmegen See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Higher or Secondary Education Establishments Administrative Contact Maarten Van Langen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG Germany EU contribution € 848 150,00 Address SANDERRING 2 97070 Wuerzburg See on map Region Bayern Unterfranken Würzburg, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Christian Gloggengiesser (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MRB Forschungszentrum fur Magnet-Resonanz-Bayern e.V. Germany EU contribution € 693 440,00 Address Am Hubland 97074 Wuerzburg See on map Activity type Research Organisations Administrative Contact Karl-Heinz Hiller (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ETABLISSEMENT FRANCAIS DU SANG France EU contribution € 634 687,00 Address AVENUE DU STADE DE FRANCE 20 93210 La Plaine Saint Denis See on map Region Ile-de-France Ile-de-France Seine-Saint-Denis Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact François Destruel (Dr.) Links Contact the organisation Opens in new window Total cost No data PROCORE LTD Israel EU contribution € 576 600,00 Address GOLDA MEIR 7 WEIZMANN SCIENCE PARK 7 70400 NES ZIONA See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Avner Yayon (Prof.) Links Contact the organisation Opens in new window Total cost No data UNIVERSITATSKLINIKUM ERLANGEN Germany EU contribution € 889 944,00 Address MAXIMILIANSPLATZ 2 91054 Erlangen See on map Region Bayern Mittelfranken Erlangen, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Katrin Faber (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data VALSTYBINIS MOKSLINIU TYRIMU INSTITUTAS INOVATYVIOS MEDICINOS CENTRAS Lithuania EU contribution € 596 712,00 Address ZYGIMANTU 9 01102 Vilnius See on map Region Lietuva Sostinės regionas Vilniaus apskritis Activity type Other Administrative Contact Jolanta Dadoniene (Prof.) Links Contact the organisation Opens in new window Total cost No data