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Dissecting the Immunological Interplay between Poverty Related Diseases and Helminth Infections: An African-European Research Initiative

Objective

Worm infections are receiving increased attention due to: the wide geographic overlap in occurrence between worms and HIV, TB and malaria; the large proportion of individuals (minimal estimates around 25%) co-infected with worms and HIV/TB/ malaria; the potential risk of increasing disease burden; the very limited understanding of the impact by worm infections on HIV-, TB- and malaria-specific immune responses and on their clinical outcome; the lack of established intervention guidelines for treatment of worm infections; and the scarce information on the impact by worm infections on vaccination and vaccine-induced immune responses. In order to address these complex and challenging scientific issues, IDEA project will focus its efforts on four primary objectives: a) the worm-induced modulation of the functional and molecular profile of HIV-, TB- and malaria-specific immune responses, b) the impact by worm co-infections on measures of disease activity of PRDs, c) the immunologic markers of worm-, HIV-, TB- and malaria-specific immune responses associated with better control of pathogen replication and disease, and d) the modulation by worm co-infections of vaccine-induced immune responses. To achieve these objectives, IDEA project has developed a global and innovative strategy which includes: a) the alliance between African and European leading scientists in the field of worms, HIV, TB and malaria, b) the multidisciplinary expertise involving immunologists, parasitologists, epidemiologists, clinicians, and experts in vaccines, c) cutting edge immunology and the most innovative technologies to profile immune response, d) the access to large cohort studies bringing a number of centres working on worms and PRDs in Africa together, and e) the access to experimental HIV, TB and malaria vaccine candidates under clinical development in Africa.
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Coordinator

CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS

Address

Rue Du Bugnon 21
1005 Lausanne

Switzerland

Activity type

Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)

EU Contribution

€ 1 623 442

Administrative Contact

Giuseppe Pantaleo (Prof.)

Participants (22)

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EUROPEAN VACCINE INITIATIVE EWIV

Germany

EU Contribution

€ 250 000

ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands

EU Contribution

€ 1 042 910

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER

United Kingdom

EU Contribution

€ 774 369,74

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

EU Contribution

€ 804 100

SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT

Switzerland

EU Contribution

€ 840 453,74

EBERHARD KARLS UNIVERSITAET TUEBINGEN

Germany

EU Contribution

€ 490 000

KENYA MEDICAL RESEARCH INSTITUTE

Kenya

EU Contribution

€ 213 700

MEDICAL RESEARCH COUNCIL

United Kingdom

EU Contribution

€ 1 449 987

Agence nationale de recherches sur le sida et les hépatites virales

France

EU Contribution

€ 3 600

ISTITUTO NAZIONALE PER LE MALATTIE INFETTIVE LAZZARO SPALLANZANI-ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO

Italy

EU Contribution

€ 333 972,94

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 247 199,70

College of Medicine, University of Ibadan

Nigeria

EU Contribution

€ 300 780

EUROVACC FOUNDATION

Switzerland

EU Contribution

€ 27 400

IFAKARA HEALTH INSTITUTE TRUST

Tanzania

EU Contribution

€ 205 400

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM

Netherlands

EU Contribution

€ 294 800

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

EU Contribution

€ 106 440

NATIONAL INSTITUTE FOR MEDICAL RESEARCH

Tanzania

EU Contribution

€ 63 400

Fondation international de l'Hopital de Dr. Albert Schweitzer de LAMBARENE

Gabon

EU Contribution

€ 218 588,19

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

Switzerland

EU Contribution

€ 119 480

MALARIA CONSORTIUM LBG

United Kingdom

VACCINE AND GENE THERAPY INSTITUTE OF FLORIDA CORP.

United States

EU Contribution

€ 497 940

Centre de Recherches Medicales de Lambaréné

Gabon

EU Contribution

€ 392 036,69

Project information

Grant agreement ID: 241642

Status

Closed project

  • Start date

    1 March 2010

  • End date

    31 August 2015

Funded under:

FP7-HEALTH

  • Overall budget:

    € 13 728 795,68

  • EU contribution

    € 10 300 000

Coordinated by:

CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS

Switzerland