Objective Filarial infections remain a major public health problem in West and Central Africa. Three filarial species are involved: Onchocerca volvulus (onchocerciasis or river blindness); Wuchereria bancrofti (lymphatic filariasis); and Loa loa (the eye worm). Treatment of onchocerciasis with ivermectin has been successful in many situations but emergence of drug resistance and risk of severe adverse reactions associated with L loa co-infections is restricting the implementation of mass treatment and consequently alternate approaches to control are required. Studies with animal models have identified the general mechanisms of protective immunity while human studies have drawn attention to immune regulatory processes that influence clinical presentations Together, these observation provide a basis for vaccine development. The next challenge is to identify target antigens and ensure appropriate formulation and delivery to promote protective responses and avoid any pathology. This project aims to: 1, use transciptomics and bioinformatics to identify the parasite molecules that are targets of protective immunity and that may influence the regulation of such responses; and 2, microarray technologies and bioinformatics to determine the pathways that lead to expression of protective immunity. Cohorts of onchocerciasis patients who have received treatment with ivermectin or tetracycline, or are co infected with either W bancrofti or L loa provide both input to the pathway studies and a means of validation of the computer assimilations. Confirmation of the mechanisms and targets of protective immunity and validation of computer assimilations will also be investigated using the O ochengi-cattle model that also enables experimentation under natural challenge. Litomosoides sigmodontis in mice provides a robust and rapid validation of results obtained from computation relating to expression and regulation of protective responses and a primary system for screening vaccine candidates Fields of science medical and health scienceshealth sciencespublic healthmedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesmedical and health sciencesbasic medicinepathology Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2009-4.3.1-1 - Discovery and development of new vaccines or drugs for helminth infections (SICA) Call for proposal FP7-HEALTH-2009-single-stage See other projects for this call Funding Scheme CP-FP-SICA - Small/medium-scale focused research project for specific cooperation actions dedicated to international cooperation partner countries(SICA) Coordinator THE UNIVERSITY OF EDINBURGH EU contribution € 1 449 784,00 Address Old college, south bridge EH8 9YL Edinburgh United Kingdom See on map Region Scotland Eastern Scotland Edinburgh Activity type Higher or Secondary Education Establishments Administrative Contact Angela Noble (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (10) Sort alphabetically Sort by EU Contribution Expand all Collapse all Research Foundation in Tropical Diseases and Environment Cameroon EU contribution € 348 898,00 Address University street 474 Buea See on map Activity type Research Organisations Administrative Contact Ayuk Peter Enyong (Dr.) Links Contact the organisation Opens in new window Total cost No data INSTITUT DE RECHERCHE AGRICOLE POUR LE DEVELOPPEMENT Cameroon EU contribution € 220 176,00 Address Po box 2123 nkolbisson 2123 Yaounde See on map Activity type Research Organisations Administrative Contact Vincent Ngwang Tanya (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY KUMASI Ghana EU contribution € 227 304,00 Address Private mail bag, university post office ASH Kumasi See on map Activity type Higher or Secondary Education Establishments Administrative Contact Sabastian Kankam (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUT NATIONAL D'HYGIENE Togo EU contribution € 215 424,00 Address Rue nangbeto 1396 Lome See on map Activity type Research Organisations Administrative Contact Meba Banla (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE UNIVERSITY OF LIVERPOOL United Kingdom EU contribution € 610 912,00 Address Brownlow hill 765 foundation building L69 7ZX Liverpool See on map Region North West (England) Merseyside Liverpool Activity type Higher or Secondary Education Establishments Administrative Contact Suzanne Halpin (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITATSKLINIKUM BONN Germany EU contribution € 559 670,00 Address Venusberg-campus 1 53127 Bonn See on map Region Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Beate Becker (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EBERHARD KARLS UNIVERSITAET TUEBINGEN Germany EU contribution € 478 516,00 Address Geschwister-scholl-platz 72074 Tuebingen See on map Region Baden-Württemberg Tübingen Tübingen, Landkreis Activity type Higher or Secondary Education Establishments Administrative Contact Peter Soboslay (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MUSEUM NATIONAL D'HISTOIRE NATURELLE France EU contribution € 489 316,00 Address Rue cuvier 57 75005 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Higher or Secondary Education Establishments Administrative Contact Coralie Martin (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FIOS GENOMICS LIMITED United Kingdom EU contribution € 400 000,00 Address Nine edinburgh bioquarter 9 little france road EH16 4UX Edinburgh See on map Region Scotland Eastern Scotland Edinburgh Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Gary Rubin (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF GLASGOW United Kingdom EU contribution No data Address University avenue G12 8QQ Glasgow See on map Region Scotland West Central Scotland Glasgow City Activity type Higher or Secondary Education Establishments Administrative Contact Joe Galloway (Mr.) Links Contact the organisation Opens in new window Website Opens in 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