CORDIS
EU research results

CORDIS

English EN
Molecular Approaches and MetaGenomic Investigations for optimizing Clean-up of PAH contaminated sites

Molecular Approaches and MetaGenomic Investigations for optimizing Clean-up of PAH contaminated sites

Objective

MAGICPAH aims to explore, understand and exploit the catalytic activities of microbial communities involved in the degradation of persistent PAHs. It will integrate (meta-) genomic studies with in-situ activity assessment based on stable isotope probing particularly in complex matrices of different terrestrial and marine environments. PAH degradation under various conditions of bioavailability will be assessed as to improve rational exploitation of the catalytic properties of bacteria for the treatment and prevention of PAH pollution. We will generate a knowledge base not only on the microbial catabolome for biodegradation of PAHs in various impacted environmental settings based on genome gazing, retrieval and characterization of specific enzymes but also on systems related bioavailability of contaminant mixtures. MAGICPAH takes into account the tremendous undiscovered metagenomic resources by the direct retrieval from genome/metagenome libraries and consequent characterization of enzymes through activity screens. These screens will include a high-end functional small-molecule fluorescence screening platform and will allow us to directly access novel metabolic reactions followed by their rational exploitation for biocatalysis and the re-construction of biodegradation networks. Results from (meta-) genomic approaches will be correlated with microbial in situ activity assessments, specifically dedicated to identifying key players and key reactions involved in anaerobic PAH metabolism. Key processes for PAH metabolism particularly in marine and composting environments and the kinetics of aerobic degradation of PAH under different conditions of bioavailability will be assessed in model systems, the rational manipulation of which will allow us to deduce correlations between system performance and genomic blueprint. The results will be used to improve treatments of PAH-contaminated sites.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH

Address

Inhoffenstrasse 7
38124 Braunschweig

Germany

Activity type

Research Organisations

EU Contribution

€ 435 890

Administrative Contact

Michael Strätz (Dr.)

Participants (13)

Sort alphabetically

Sort by EU Contribution

Expand all

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

EU Contribution

€ 296 745

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

EU Contribution

€ 303 534

BANGOR UNIVERSITY

United Kingdom

EU Contribution

€ 301 296

DANMARKS TEKNISKE UNIVERSITET

Denmark

EU Contribution

€ 274 524

AECOM CZ SRO

Czechia

EU Contribution

€ 171 155

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

EU Contribution

€ 284 505

HELMHOLTZ-ZENTRUM FUR UMWELTFORSCHUNG GMBH - UFZ

Germany

EU Contribution

€ 305 475

AARHUS UNIVERSITET

Denmark

EU Contribution

€ 320 160

SYNDIAL SPA - ATTIVITA DIVERSIFICATE

Italy

EU Contribution

€ 50 005

CORPORACION CORPOGEN

Colombia

EU Contribution

€ 139 086

THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

Canada

UNIVERSITAET LEIPZIG

Germany

EU Contribution

€ 89 871,04

ALBERT-LUDWIGS-UNIVERSITAET FREIBURG

Germany

EU Contribution

€ 24 890,96

Project information

Grant agreement ID: 245226

Status

Closed project

  • Start date

    1 April 2010

  • End date

    31 March 2014

Funded under:

FP7-KBBE

  • Overall budget:

    € 4 515 496

  • EU contribution

    € 2 997 137

Coordinated by:

HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH

Germany