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Biosensor nanoarrays for environmental monitoring

Objective

BIOMONAR develops multiplexed nanoarray biosensors for environmental targets, i.e. pollutants and pathogens. The innovative approach engineers three sensor platforms (surface, liposomal, living cell) which exploit a panel of periplasmic binding proteins (PBPs) as the common selective element. The nanoarrays are integrated into a microfluidics system for in-situ monitoring. The strategy allows for selective and sensitive detection of target compounds in complex environmental mixtures. The sensor platforms probe different aspects in the ‘exposure to effect’ chain of processes: each responds to a certain proportion of the total target concentration and has a characteristic dynamic window. The sensor signals are quantitatively interpreted and represented in terms of the spectra of reactivities and fluxes of the target compounds. This level of sophistication, coupled with the common PBP selective component, allows a coherent elucidation of the link between dynamic target speciation and predicted ecotoxicological impact. The optimisation and dedication of the sensors for environmental monitoring inherently involves physicochemical characterisation of the various bio/nonbio and bio/bio interfacial processes at nanoscale. The ensuing knowledge on the interaction of nanostructured surfaces with biological systems facilitates design of sensors for new targets, thus providing technical opportunities for the biosensor industry.

Call for proposal

FP7-KBBE-2009-3
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Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

SYDDANSK UNIVERSITET
Address
Campusvej 55
5230 Odense M
Denmark
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 508 558
Administrative Contact
Raewyn M. Town (Prof.)

Participants (9)

UNIVERSITE DE LAUSANNE
Switzerland
EU contribution
€ 471 561
Address
Quartier Unil-centre Bâtiment Unicentre
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jan Roelof Van Der Meer (Prof.)
JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION
Belgium
EU contribution
€ 278 556
Address
Rue De La Loi 200
1049 Brussels
Activity type
Research Organisations
Administrative Contact
Iain Formosa (Mr.)
WAGENINGEN UNIVERSITY
Netherlands
EU contribution
€ 462 954
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anita Ter Haar (Ms.)
THE HEBREW UNIVERSITY OF JERUSALEM
Israel
EU contribution
€ 343 759
Address
Edmond J Safra Campus Givat Ram
91904 Jerusalem
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jane Turner (Ms.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 393 078
Address
Rue Michel Ange 3
75794 Paris
Activity type
Other
Administrative Contact
Michel Mauvais (Mr.)
CORNELL UNIVERSITY
United States
EU contribution
€ 156 779
Address
Pine Tree Road 373
14850 Ithaca Ny
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Antje Baeumner (Prof.)
LIONIX BV
Netherlands
EU contribution
€ 235 491
Address
Hengelosestraat 500
7521 AN Enschede
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Henk Leeuwis (Mr.)
MICRODISH BV
Netherlands
EU contribution
€ 106 750
Address
Schipholweg 275
1171 PK Badhoevedorp
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Martin Hessing (Dr.)
METROHM-APPLIKON
Netherlands
EU contribution
€ 40 000
Address
De Brauwweg 13
3125AE Schiedam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Timoer Frelink (Dr.)