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Activation of vasculature associated stem cells and muscle stem cells for the repair and maintenance of muscle tissue

Activation of vasculature associated stem cells and muscle stem cells for the repair and maintenance of muscle tissue

Objective

We propose to develop new strategies to mobilize skeletal muscle tissue-associated stem cells as a tool for efficient tissue repair. This will be combined with exploring novel approaches that limit tissue damage, and will focus on agents that modify muscle and muscle vasculature progenitor cells. These molecules include nitric oxide associated with non-steroidal anti-inflammatory drugs, HMGB1, Cripto, NAC, and present and improved deacetylase inhibitors. Three clinical trials will be run in tandem with efforts to dissect the underlying mechanisms of action. Importantly, we have already initiated a monocentric clinical trial that focuses on the efficacy of NO-donors plus NSAIDs in muscle pathologies. Our efforts will be complemented by novel biodelivery systems for effective targeting. Our efforts will be complemented by novel biodelivery systems for effective targeting. The most promising drugs, used alone or in combination, will be first validated in small and large animal models. Our project brings together leading investigators to examine how vascular and muscle progenitors participate in postnatal growth and muscle tissue repair. A key issue that this project addresses is the tissue environment in which endogenous stem cells are activated. We propose that muscle degeneration and fibrosis provokes altered vascularization and immune responses, which eventually affect negatively stem cell functions. Molecules that can be used to therapeutically target these key cells, and their communication with neighboring vascular, inflammatory and fibrotic cell types, will lead to more effective approaches to muscle regenerative medicine and to novel cures for degenerative diseases, including atherosclerosis, vascular damage in diabetes and in peripheral ischemic vascular disease.
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Coordinator

UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6

Address

Place Jussieu 4
75252 Paris

France

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 871 947,44

Administrative Contact

Lucie Salvaudon (Dr.)

Participants (21)

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CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

EU Contribution

€ 639 300

IRCCS - ASSOCIAZIONE LA NOSTRA FAMIGLIA 'ISTITUTO SCIENTIFICO EUGENIO MEDEA'

Italy

EU Contribution

€ 750 200

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

Switzerland

EU Contribution

€ 490 500

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

EU Contribution

€ 513 300

NOVARTIS PHARMA AG

Switzerland

EU Contribution

€ 259 100

Fondazione Centro San Raffaele

Italy

IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE

Italy

EU Contribution

€ 463 700

FONDAZIONE TELETHON

Italy

EU Contribution

€ 278 077,20

UNIVERSIDAD POMPEU FABRA

Spain

EU Contribution

€ 751 300

JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN

Germany

EU Contribution

€ 489 300

HMGBiotech s.r.l.

Italy

EU Contribution

€ 552 500

CORETHERAPIX S.L

Spain

DANDO WEISS & COLUCCI LIMITED

United Kingdom

EU Contribution

€ 299 524,17

ACCELERON MEDICINES LTD

United Kingdom

LIVERPOOL JOHN MOORES UNIVERSITY

United Kingdom

EU Contribution

€ 256 248

ITALFARMACO SPA

Italy

EU Contribution

€ 683 400

SANTHERA PHARMACEUTICALS (SCHWEIZ) AG

Switzerland

EU Contribution

€ 748 800

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 1 850 008,40

KING'S COLLEGE LONDON

United Kingdom

EU Contribution

€ 452 289,04

FONDAZIONE SANTA LUCIA

Italy

EU Contribution

€ 164 385,75

Fondazione Centro San Raffaele

Italy

EU Contribution

€ 483 700

Project information

Grant agreement ID: 241440

Status

Closed project

  • Start date

    1 January 2010

  • End date

    31 December 2014

Funded under:

FP7-HEALTH

  • Overall budget:

    € 16 340 569,28

  • EU contribution

    € 11 997 580

Coordinated by:

UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6

France

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