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Activation of vasculature associated stem cells and muscle stem cells for the repair and maintenance of muscle tissue

Objective

We propose to develop new strategies to mobilize skeletal muscle tissue-associated stem cells as a tool for efficient tissue repair. This will be combined with exploring novel approaches that limit tissue damage, and will focus on agents that modify muscle and muscle vasculature progenitor cells. These molecules include nitric oxide associated with non-steroidal anti-inflammatory drugs, HMGB1, Cripto, NAC, and present and improved deacetylase inhibitors. Three clinical trials will be run in tandem with efforts to dissect the underlying mechanisms of action. Importantly, we have already initiated a monocentric clinical trial that focuses on the efficacy of NO-donors plus NSAIDs in muscle pathologies. Our efforts will be complemented by novel biodelivery systems for effective targeting. Our efforts will be complemented by novel biodelivery systems for effective targeting. The most promising drugs, used alone or in combination, will be first validated in small and large animal models. Our project brings together leading investigators to examine how vascular and muscle progenitors participate in postnatal growth and muscle tissue repair. A key issue that this project addresses is the tissue environment in which endogenous stem cells are activated. We propose that muscle degeneration and fibrosis provokes altered vascularization and immune responses, which eventually affect negatively stem cell functions. Molecules that can be used to therapeutically target these key cells, and their communication with neighboring vascular, inflammatory and fibrotic cell types, will lead to more effective approaches to muscle regenerative medicine and to novel cures for degenerative diseases, including atherosclerosis, vascular damage in diabetes and in peripheral ischemic vascular disease.

Field of science

  • /medical and health sciences/basic medicine/pathology
  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /medical and health sciences/clinical medicine/endocrinology/diabetes
  • /medical and health sciences/clinical medicine/cardiology/cardiovascular diseases/arteriosclerosis

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6
Address
Place Jussieu 4
75252 Paris
France
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 871 947,44
Administrative Contact
Lucie Salvaudon (Dr.)

Participants (21)

CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 639 300
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
Administrative Contact
Alfredo Di Giacomo (Mr.)
IRCCS - ASSOCIAZIONE LA NOSTRA FAMIGLIA 'ISTITUTO SCIENTIFICO EUGENIO MEDEA'
Italy
EU contribution
€ 750 200
Address
Via Don Luigi Monza 1
22037 Ponte Lambro
Activity type
Research Organisations
Administrative Contact
Laura Nulli (Dr.)
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
EU contribution
€ 490 500
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christina Mattsson (Ms.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 513 300
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
Administrative Contact
Keith Williamson (Mr.)
NOVARTIS PHARMA AG
Switzerland
EU contribution
€ 259 100
Address
Lichtstrasse 35
4056 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Andrew Mackenzie (Dr.)
FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR
Italy
Address
Via Olgettina 60
20132 Milano
Activity type
Research Organisations
Administrative Contact
Mario Valsecchi (Mr.)
IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE
Italy
EU contribution
€ 463 700
Address
Via Adamello 16
20139 Milano
Activity type
Research Organisations
Administrative Contact
Raffaela Zoboli (Ms.)
FONDAZIONE TELETHON

Participation ended

Italy
EU contribution
€ 278 077,20
Address
Via Varese 16/B
00185 Roma
Activity type
Research Organisations
Administrative Contact
Irene Mearelli (Ms.)
UNIVERSIDAD POMPEU FABRA
Spain
EU contribution
€ 751 300
Address
Placa De La Merce, 10-12
08002 Barcelona
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eva Martin (Ms.)
JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN
Germany
EU contribution
€ 489 300
Address
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mareike Schmitt (Ms.)
HMGBIOTECH SRL
Italy
EU contribution
€ 552 500
Address
Piazzale Gorini Paolo 8
20133 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michele Sagramoso (Dr.)
CORETHERAPIX S.L

Participation ended

Spain
Address
Plaza De La Encina 10 Nucleo 1 Planta 3
28760 Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Juan Sebastián Ruiz-Constantino Fernández (Prof.)
DANDO WEISS & COLUCCI LIMITED

Participation ended

United Kingdom
EU contribution
€ 299 524,17
Address
Lower Bristol Road Minerva House
BA2 9ER Bath
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jeffrey Dando (Mr.)
ACCELERON MEDICINES LTD

Participation ended

United Kingdom
Address
New Street Square 5
EC4A 3TW London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
John Quisel (Mr.)
LIVERPOOL JOHN MOORES UNIVERSITY

Participation ended

United Kingdom
EU contribution
€ 256 248
Address
Rodney Street 2 Egerton Court
L3 5UX Liverpool
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ian Pennington (Mr.)
ITALFARMACO SPA
Italy
EU contribution
€ 683 400
Address
Viale Fulvio Testi 330
20126 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marco Zotti (Dr.)
SANTHERA PHARMACEUTICALS (SCHWEIZ) AG
Switzerland
EU contribution
€ 748 800
Address
Hammerstrasse 49
4410 Liestal
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Stephan Haefelfinger (Mr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 1 850 008,40
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Mihaja Auguste (Ms.)
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 452 289,04
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Labbett (Mr.)
FONDAZIONE SANTA LUCIA
Italy
EU contribution
€ 164 385,75
Address
Via Ardeatina 306
00179 Roma
Activity type
Research Organisations
Administrative Contact
Antonio Ierna (Dr.)
FONDAZIONE CENTRO SAN RAFFAELE
Italy
EU contribution
€ 483 700
Address
Via Olgettina 60
20132 Milano
Activity type
Research Organisations
Administrative Contact
Maria Rosa Pedrazzi (Dr.)