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OPtimization of Treatment and Management of Schizophrenia in Europe (OPTiMiSE)

Project information

Grant agreement ID: 242114

Status

Closed project

  • Start date

    1 February 2010

  • End date

    31 July 2016

Funded under:

FP7-HEALTH

  • Overall budget:

    € 14 900 190,31

  • EU contribution

    € 11 187 685,42

Coordinated by:

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Netherlands

Objective

OPTiMiSE (OPtimization of Treatment and Management of Schizophrenia in Europe) will focus on two goals: optimising current treatments in Schizophrenia and explore novel therapeutic options for schizophrenia. The project intends to both address basic, but so far unanswered, questions in the treatment of schizophrenia and develop new and experimental interventions. It is expected that the project will lead to evidence that is directly applicable to treatment guidelines, will explore the development of novel treatments and will identify potential mechanisms for new drug development. To achieve these goals we have assembled a European team of experts that is second to none in the world. Together we will pursue the following objectives: -To use MRI to optimise treatment outcome and to facilitate prediction of response to treatment; - To provide a rational basis for antipsychotic choices in the treatment of first episode schizophrenia or schizophreniform disorder; - To improve functional outcome and reduce drug discontinuation by means of psychosocial interventions. - To explore the potential of cannabidiol CBD, a modulator of endocannabinoid functioning, as an alternative to D2 based antipsychotics - To validate a new approach to improve cognitive performance in patients with cognitive deficits on the basis of their genetic make up; - To use theoretically driven neurochemical imaging (MRS) and empirically driven genetic/genomic markers as predictors of response to treatment.

Coordinator

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Address

Heidelberglaan 100
3584 Cx Utrecht

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 3 205 464,06

Administrative Contact

Mirjam Lormans (Ms.)

Participants (22)

KING'S COLLEGE LONDON

United Kingdom

EU Contribution

€ 1 725 194,26

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 591 356,36

THE UNIVERSITY OF MANCHESTER

United Kingdom

EU Contribution

€ 408 047

ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT

Germany

EU Contribution

€ 970 695

KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN

Germany

EU Contribution

€ 450 136

REGION HOVEDSTADEN

Denmark

EU Contribution

€ 714 003,64

SERVICIO MADRILENO DE SALUD

Spain

EU Contribution

€ 742 961,28

MEDIZINISCHE UNIVERSITAT INNSBRUCK

Austria

EU Contribution

€ 78 705,36

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

EU Contribution

€ 22 784,38

MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER

Israel

EU Contribution

€ 224 072,95

UNIWERSYTET MEDYCZNY IM KAROLA MARCINKOWSKIEGO W POZNANIU

Poland

EU Contribution

€ 175 846,80

Clienia Schloessli AG

Switzerland

EU Contribution

€ 214 537,80

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

EU Contribution

€ 200 319,90

UNIVERSITA DEGLI STUDI DELLA CAMPANIA LUIGI VANVITELLI

Italy

EU Contribution

€ 234 899,76

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

Germany

EU Contribution

€ 213 204

TANGENT DATA SRL

Romania

EU Contribution

€ 446 620,20

UNIVERZITA KARLOVA

Czechia

EU Contribution

€ 103 949,44

PSYCHIATRICKE CENTRUM PRAHA

Czechia

EU Contribution

€ 13 172,40

MARTIN-LUTHER-UNIVERSITAET HALLE-WITTENBERG

Germany

EU Contribution

€ 71 900,40

Fondation FondaMental

France

EU Contribution

€ 215 537,23

UNIVERSITATSKLINIKUM HEIDELBERG

Germany

EU Contribution

€ 71 900,40

SPETSIALIZIRANA BOLNITSA ZA AKTIVNO LECHENIE PO NEVROLOGIA I PSIHIATRIA SV NAUM AD

Bulgaria

EU Contribution

€ 92 376,80

Project information

Grant agreement ID: 242114

Status

Closed project

  • Start date

    1 February 2010

  • End date

    31 July 2016

Funded under:

FP7-HEALTH

  • Overall budget:

    € 14 900 190,31

  • EU contribution

    € 11 187 685,42

Coordinated by:

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Netherlands