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SUstainable PROduction of GALanthamine by both in vitro and agricultural crops of highly galanthamine-containing plants

Objective

Galanthamine is an alkaloid produced exclusively by plants of the family Amaryllidaceae, mainly belonging to the genus Galanthus, Leucojum and Narcissus. Owing to its acetylcholinesterase inhibitory activity, galanthamine is used and marketed for the treatment of the Alzheimer’s disease, among others. Although it is obtained by organic synthesis, galanthamine is also being extracted from natural sources. Both Galanthus and Leucojum plants are very widespread in the Eastern European countries, whereas Narcissus plants are mainly distributed in the Mediterranean region. For industrial purposes, Leucojum aestivum plants are gathered from wild populations in their natural habitat, which causes increasing problems regarding quality of the plant material as well as depletion pressure on the natural populations of L. aestivum. By development of an in vitro production method, both problems will be overcome. Narcissus confusus, an endemic species growing in Spain, was found to produce around two-fold higher amount of galanthamine than L. aestivum. Both plant species will also be propagated and subjected to further agronomic studies for the initiation of new crops of highly galanthamine-containing plants. Integrating both research approaches, the initiation of new crops of L. aestivum and N. confusus and the establishment of the in vitro production method, will result in the development of a sustainable production method of galanthamine. Since galanthamine in Europe is produced by highly specialised SMEs, significant improvement in this field can only be achieved by cooperation on European level. The co-operative research implemented in the SUPROGAL project will thus markedly improve the competitiveness of the involved SMEs.

Field of science

  • /social sciences/economics and business/economics/sustainable economy
  • /agricultural sciences/agriculture, forestry, and fisheries/agriculture/plant breeding/crops

Call for proposal

FP7-SME-2007-1
See other projects for this call

Funding Scheme

BSG-SME - Research for SMEs

Coordinator

UNIVERSITAT DE BARCELONA
Address
Gran Via De Les Corts Catalanes 585
08007 Barcelona
Spain
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Carles Codina (Prof.)

Participants (6)

BULPHYTOOILS JOINTSTOCK COMPANY BPHO
Bulgaria
EU contribution
€ 152 240
Address
Tvardishki Prohod Street 23 Office 4
1404 Sofia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Dimitar Shopov (Mr.)
VITROFLORA Laboratorium Kultur Tkankowych
Poland
EU contribution
€ 232 815
Address
Ul. Bukowa 3
86 065 Lochowo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Anna Pawlak (Mrs.)
BV AMARYLLIS KWEEKERIJ LUDWIG & CO
Netherlands
EU contribution
€ 221 980
Address
Middenweg 13
2161 LR Lisse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Rudolf Berbee (Mr.)
AGROBIOINSTITUTE
Bulgaria
Address
Bul. Dragan Tzankov 8
1164 Sofia
Activity type
Research Organisations
Administrative Contact
Violeta Kondakova (Dr.)
BIOPLANTA GmbH
Germany
Address
Deutscher Platz 5
04103 Leipzig
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Dirk Wilken (Dr.)
Holland Biodiversity B.V.
Netherlands
EU contribution
€ 180 125
Address
Middenweg 13
2161 LR Lisse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Diane Bentvelzen (Ms.)