Objective Tuberculosis (TB) is a re-emerging global health threat caused by Mycobacterium tuberculosis (Mtb). One third of the world's population is infected with Mtb and new infections occur at a rate of one per second. Despite global research efforts, mechanisms underlying pathogenesis, virulence and persistence of Mtb infection remain poorly understood. Simple reductionist approaches are insufficient to understand its complex biology. The grand goal of the SysteMTb project is to establish a Systems Biology framework to understand key features of Mtb and its interactions with the host which, in turn, will provide new insights and a solid (model based) knowledge for the development of novel and cost-effective strategies to combat tuberculosis. To achieve this, SysteMTb will: i) generate and integrate quantitative data sets of Mtb (e.g. transcriptomics, proteomics, metabolomics, structural genomics, lipidomics, glycomics) alone, or in the presence of host macrophages, ii) develop computer models at different appropriate levels of system complexity with emphasis on metabolism, regulatory networks and transcription regulation, and iii) identify new possible targets for therapeutic intervention based on computer modelling. The combination of these approaches will provide a rational framework to understand mycobacterial physiology during infection and to identify essential nodes that are optimal for effective therapeutic interventions. Fields of science natural sciencesbiological sciencesgeneticsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health sciencesclinical medicinepneumologytuberculosismedical and health sciencesbasic medicinephysiology Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2009-2.1.2-1 - Systems biology approaches for basic biological processes relevant to health and disease Call for proposal FP7-HEALTH-2009-two-stage See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator FUNDACIO CENTRE DE REGULACIO GENOMICA EU contribution € 1 528 837,00 Address CARRER DOCTOR AIGUADER 88 08003 Barcelona Spain See on map Region Este Cataluña Barcelona Activity type Research Organisations Administrative Contact Michela Bertero (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (13) Sort alphabetically Sort by EU Contribution Expand all Collapse all MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Germany EU contribution € 1 034 185,00 Address HOFGARTENSTRASSE 8 80539 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Birgit Gieding (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MEDICAL RESEARCH COUNCIL United Kingdom EU contribution € 895 544,00 Address 20 Park Crescent W1B 1AL LONDON See on map Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact John Wills (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France EU contribution € 688 948,00 Address RUE MICHEL ANGE 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Patrick Mounaud (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Switzerland EU contribution € 1 345 851,00 Address Raemistrasse 101 8092 Zuerich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Administrative Contact Rudolf Aebersold (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTYTUT BIOCHEMII I BIOFIZYKI POLSKIEJ AKADEMII NAUK Poland EU contribution € 643 110,00 Address PAWINSKIEGO 5A 02 106 Warszawa See on map Region Makroregion województwo mazowieckie Warszawski stołeczny Miasto Warszawa Activity type Research Organisations Administrative Contact Agata Rogowska (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data USTAV ORGANICKE CHEMIE A BIOCHEMIE, AV CR, V.V.I. Czechia EU contribution € 485 521,00 Address FLEMINGOVO NAM. 542/2 16610 Praha 6 See on map Region Česko Praha Hlavní město Praha Activity type Research Organisations Administrative Contact Renata Sroglova (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EUROPEAN MOLECULAR BIOLOGY LABORATORY Germany EU contribution € 1 308 514,00 Address Meyerhofstrasse 1 69117 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Research Organisations Administrative Contact Ivanka Araujo (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO Italy EU contribution € 369 600,00 Address DUOMO 6 13100 Vercelli See on map Region Nord-Ovest Piemonte Vercelli Activity type Higher or Secondary Education Establishments Administrative Contact Carlo Muzio (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data OMNIA MOLECULAR S.L. Spain EU contribution € 460 000,00 Address Calle JOSEP SAMITIER - PARC CIENTIFIC DE BARCELONA 1-5 08028 BARCELONA See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Maurici Torra Juanola (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data LIONEX GMBH Germany EU contribution € 479 240,00 Address Salzdahlumer Strasse 196 38126 Braunschweig See on map Region Niedersachsen Braunschweig Braunschweig, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Mahavir Singh (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HUMBOLDT-UNIVERSITAET ZU BERLIN Germany EU contribution € 467 100,00 Address UNTER DEN LINDEN 6 10117 Berlin See on map Region Berlin Berlin Berlin Activity type Higher or Secondary Education Establishments Administrative Contact Brigitte Lehmann (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data WAGENINGEN UNIVERSITY Netherlands EU contribution € 748 151,00 Address DROEVENDAALSESTEEG 4 6708 PB Wageningen See on map Region Oost-Nederland Gelderland Veluwe Activity type Higher or Secondary Education Establishments Administrative Contact Jos Teunissen Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KATHOLIEKE UNIVERSITEIT LEUVEN Belgium EU contribution € 108 000,00 Address OUDE MARKT 13 3000 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Administrative Contact Karolien Mariën (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
