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Cancer Genomics of the Kidney

Objective

The International Cancer Genome Consortium (ICGC) has the goal of obtaining a comprehensive description of genomic, transcriptomic and epigenomic changes in 50 different tumour types and/or subtypes, with the aim of elucidating the genomic changes present in the many forms of cancers that contribute to the burden of disease throughout the world. We present a proposal for a European contribution to this effort through application of state-of-the-art approaches to the genomics of the most common form of renal cell cancer (RCC). RCC is of particular importance within Europe where the highest global incidence rates are observed. Disease incidence has increased over the last two decades, and it is now the 8th most common cancer in the EU. CAGEKID brings clinical and epidemiological resources that are unique worldwide together with the necessary genetics and genomics expertise required for this effort. In the first phase of the study, we will provide a full genomic characterisation of 100 matched pairs of DNA extracted from the tumour and constitutional samples. DNA will be completely sequenced, and the data brought together with those from whole genome transcript and methylation analyses. Follow-up studies of potential targets will be made in further samples. The results acquired will be relied to targeted protein analyses. The primary data will be made available to the scientific community, and the programme will contribute to establishing norms for the manipulation and storage of biological samples. CAGEKID will provide the first systematic analysis of this tumour site providing new insights into disease aetiology with application for diagnosis and treatment. It addresses a major need to identify new biological markers for renal cell cancer, one of very few tumour types for which there are currently no biological markers in routine clinical use. Renal cancer is not yet supported by any of the members of the ICGC.

Field of science

  • /medical and health sciences/clinical medicine/oncology/cancer
  • /natural sciences/biological sciences/genetics and heredity/genome

Call for proposal

FP7-HEALTH-2009-two-stage
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

FONDATION JEAN DAUSSET CENTRE D'ETUDE DU POLYMORPHISME HUMAIN FONDATION
Address
Rue Juliette Dodu 27
75010 Paris 10
France
Activity type
Research Organisations
EU contribution
€ 3 007 900,01
Administrative Contact
Jean-François Deleuze (Dr.)

Participants (14)

CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER
France
EU contribution
€ 1 126 500
Address
150 Cours Albert Thomas
69372 Lyon Cedex 08
Activity type
Other
Administrative Contact
Olaf Kelm (Dr.)
UNIVERZITA KARLOVA
Czechia
EU contribution
€ 175 500
Address
Ovocny Trh 560/5
116 36 Praha 1
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kristyna Matejkova
PROTIVORAKOVOE OBSHESTVO ROSSII
Russia
EU contribution
€ 530 500
Address
Kashirskoye Shosse 24
115478 Moskva
Activity type
Research Organisations
Administrative Contact
David Zaridze (Prof.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 485 375
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
Administrative Contact
Tom Ratcliff (Mr.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 514 099
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kristina Geiger (Ms.)
Centre Bioengineering of the Russian academy of sciences
Russia
EU contribution
€ 815 151,41
Address
Prosp. 60-Let Oktiabria 7-1
117312 Moscow
Activity type
Research Organisations
Administrative Contact
Nikolay Ravin (Dr.)
UNIVERSITY OF LEEDS
United Kingdom
EU contribution
€ 691 930,72
Address
Woodhouse Lane
LS2 9JT Leeds
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kathy Brownridge (Ms.)
KUNGLIGA TEKNISKA HOEGSKOLAN
Sweden
EU contribution
€ 34 244
Address
Brinellvagen 8
100 44 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ake Eriksson (Mr.)
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 1 852 326
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
Administrative Contact
Elizabeth May (Ms.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 285 600
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Cédrine Pederiva (Ms.)
LATVIJAS UNIVERSITATES MATEMATIKAS UN INFORMATIKAS INSTITUTS
Latvia
EU contribution
€ 149 774
Address
Raina Bulvaris 29
1459 Riga
Activity type
Research Organisations
Administrative Contact
Inara Opmane (Ms.)
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 27 007
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Fredrik Ponten (Prof.)
RUSSIAN RESEARCH CENTRE KURCHATOV INSTITUTE
Russia
EU contribution
€ 804 092,86
Address
Kurchatov Square 1
123182 Moscow
Activity type
Research Organisations
Administrative Contact
Oleg Akilin (Mr.)
ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING MCGILL UNIVERSITY
Canada
Address
845 Sherbrooke Street West
H3A0G4 Montreal
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Olga Naiberger (Ms.)