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Cancer Genomics of the Kidney

Cancer Genomics of the Kidney

Objective

The International Cancer Genome Consortium (ICGC) has the goal of obtaining a comprehensive description of genomic, transcriptomic and epigenomic changes in 50 different tumour types and/or subtypes, with the aim of elucidating the genomic changes present in the many forms of cancers that contribute to the burden of disease throughout the world. We present a proposal for a European contribution to this effort through application of state-of-the-art approaches to the genomics of the most common form of renal cell cancer (RCC). RCC is of particular importance within Europe where the highest global incidence rates are observed. Disease incidence has increased over the last two decades, and it is now the 8th most common cancer in the EU. CAGEKID brings clinical and epidemiological resources that are unique worldwide together with the necessary genetics and genomics expertise required for this effort. In the first phase of the study, we will provide a full genomic characterisation of 100 matched pairs of DNA extracted from the tumour and constitutional samples. DNA will be completely sequenced, and the data brought together with those from whole genome transcript and methylation analyses. Follow-up studies of potential targets will be made in further samples. The results acquired will be relied to targeted protein analyses. The primary data will be made available to the scientific community, and the programme will contribute to establishing norms for the manipulation and storage of biological samples. CAGEKID will provide the first systematic analysis of this tumour site providing new insights into disease aetiology with application for diagnosis and treatment. It addresses a major need to identify new biological markers for renal cell cancer, one of very few tumour types for which there are currently no biological markers in routine clinical use. Renal cancer is not yet supported by any of the members of the ICGC.

Coordinator

FONDATION JEAN DAUSSET CENTRE D'ETUDE DU POLYMORPHISME HUMAIN FONDATION

Address

Rue Juliette Dodu 27
75010 Paris 10

France

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 3 007 900,01

Administrative Contact

Jean-François Deleuze (Dr.)

Participants (14)

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CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER

France

EU Contribution

€ 1 126 500

UNIVERZITA KARLOVA

Czechia

EU Contribution

€ 175 500

PROTIVORAKOVOE OBSHESTVO ROSSII

Russia

EU Contribution

€ 530 500

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

EU Contribution

€ 485 375

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 514 099

Centre Bioengineering of the Russian academy of sciences

Russia

EU Contribution

€ 815 151,41

UNIVERSITY OF LEEDS

United Kingdom

EU Contribution

€ 691 930,72

KUNGLIGA TEKNISKA HOEGSKOLAN

Sweden

EU Contribution

€ 34 244

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

EU Contribution

€ 1 852 326

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 285 600

LATVIJAS UNIVERSITATES MATEMATIKAS UN INFORMATIKAS INSTITUTS

Latvia

EU Contribution

€ 149 774

UPPSALA UNIVERSITET

Sweden

EU Contribution

€ 27 007

RUSSIAN RESEARCH CENTRE KURCHATOV INSTITUTE

Russia

EU Contribution

€ 804 092,86

ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING MCGILL UNIVERSITY

Canada

Project information

Grant agreement ID: 241669

Status

Closed project

  • Start date

    1 March 2010

  • End date

    31 August 2014

Funded under:

FP7-HEALTH

  • Overall budget:

    € 13 747 768,05

  • EU contribution

    € 10 500 000

Coordinated by:

FONDATION JEAN DAUSSET CENTRE D'ETUDE DU POLYMORPHISME HUMAIN FONDATION

France