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health-economic modelling of PREvention strategies for Hpv-related Diseases in European CounTries

health-economic modelling of PREvention strategies for Hpv-related Diseases in European CounTries

Objective

The goals of the PREHDICT study are to determine prerequisites and strategies for vaccination in European countries and to predict the impact of vaccination on screening programmes. To achieve these goals, a multiple HPV type transmission model will be built to describe the type-specific incidence and clearance of HPV infections. This model will be linked to an individual-based simulation model used for modelling the impact of screening. For HPV-related diseases other than cervical cancer and genital warts, Markov models will be developed after critical review of the role of HPV. In the PREHDICT study, country-specific cost-effectiveness analyses will be performed for the vaccination and include determination of the vaccination age, the number of doses, the vaccination population, and the optimal catch-up vaccination age. Furthermore, the impact of vaccination on screening programmes will be assessed. This involves determination of the screening technology, screening frequency, and follow-up management of test-positive women. Special attention will be given to screening attendance and its relation to vaccination attendance. To have models with strong empirical support, the PREHDICT team will collect the most updated data on HPV infection, HPV-related disease, life-style factors, and demographics. Furthermore, HPV-type specific analyses will be performed on the outcomes of a vaccination trial, 3 large screening trials, and one self-sampling trial for screening non-attenders. By meta-analytical techniques, results will be pooled. The costs involved in the calculations will include the costs of organizing, running, and monitoring a vaccination and/or screening programme. The results of the PREHDICT study will be published in international peer-reviewed journals, posted on the WHO HPV information centre website and will also be systematically disseminated to all major stakeholders, in particular to decision makers at European, national and sub-national levels.
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Coordinator

STICHTING VU

Address

De Boelelaan 1105
1081 Hv Amsterdam

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 878 405

Administrative Contact

Johannes Berkhof (Dr.)

Participants (12)

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AZIENDA OSPEDALIERA SAN GIOVANNI BATTISTA DI TORINO

Italy

EU Contribution

€ 335 600

FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE

Spain

AZIENDA OSPEDALIERA CITTA DELLA SALUTE E DELLA SCIENZA DI TORINO

Italy

LUNDS UNIVERSITET

Sweden

EU Contribution

€ 23 810

TAMPEREEN YLIOPISTO

Finland

EU Contribution

€ 298 538

INSTITUT SCIENTIFIQUE DE SANTE PUBLIQUE

Belgium

EU Contribution

€ 252 664

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER

United Kingdom

EU Contribution

€ 264 107

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

EU Contribution

€ 162 668

European Cervical Cancer Asociation

France

EU Contribution

€ 67 548

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 289 890

INSTITUT CATALA D'ONCOLOGIA

Spain

EU Contribution

€ 390 302

VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG

Netherlands

Project information

Grant agreement ID: 242061

Status

Closed project

  • Start date

    1 May 2010

  • End date

    30 April 2013

Funded under:

FP7-HEALTH

  • Overall budget:

    € 3 774 909,60

  • EU contribution

    € 2 963 532

Coordinated by:

STICHTING VU

Netherlands