CORDIS
EU research results

CORDIS

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Role of Quorum Sensing mechanisms in the Immune System s regulation

Project information

Grant agreement ID: 249740

Status

Closed project

  • Start date

    1 June 2010

  • End date

    31 May 2015

Funded under:

FP7-IDEAS-ERC

  • Overall budget:

    € 2 105 950

  • EU contribution

    € 2 105 950

Hosted by:

INSTITUT PASTEUR

France

Objective

The homeostatic control of lymphocyte numbers provides the immune system with a basic mechanism that shapes the repertoire of the immune-competent cells and therefore, the capacity to respond to exogenous antigens as well as to maintain self-tolerance. Homeostatic mechanisms will also enable the re-establishment of the immune system following disruption (irradiation or chemotherapy). During the process of restoration, the immune system can be reset at a new equilibrium overcoming any of its previous malfunctions. This capacity of homeostatic regulation may therefore be used in potential therapeutic strategies to radically modify lymphocyte repertoires, immune responses, autoimmune disease and allergy. We now postulate that control of lymphocyte numbers may be achieved by the ability of lymphocytes to perceive the density of their own populations. Lymphocytes may use quorum-sensing mechanisms to coordinate their gene expression according to the density of their population, as long as lymphocytes have (a) a mean of assessing the number of components they interact with and (b) a standard response once a threshold number of components is detected. To address the role of quorum-sensing in the Immune System this project aims: 1) To study the role of quorum-sensing mechanisms in the homeostasis of natural activated IgM-secreting and memory B cell populations, by studying the role of secreted IgG in these processes. 2) To determine the role of quorum-sensing mechanisms associated with the homeostasis of naïve and regulatory CD4+ T cells, by studying the role of IL-2 titers in T cell homeostasis. This project has a major potential impact in medical care, addresses new lines of research and uses original experimental strategies and models that we devised in the laboratory.
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Principal Investigator

Antonio Angelo Bastos Alves De Freitas (Prof.)

Host institution

INSTITUT PASTEUR

Address

Rue Du Docteur Roux 25-28
75724 Paris Cedex 15

France

Activity type

Research Organisations

EU Contribution

€ 2 105 950

Principal Investigator

Antonio Angelo Bastos Alves De Freitas (Prof.)

Administrative Contact

Marie-Laure Rosso (Ms.)

Beneficiaries (1)

INSTITUT PASTEUR

France

EU Contribution

€ 2 105 950

Project information

Grant agreement ID: 249740

Status

Closed project

  • Start date

    1 June 2010

  • End date

    31 May 2015

Funded under:

FP7-IDEAS-ERC

  • Overall budget:

    € 2 105 950

  • EU contribution

    € 2 105 950

Hosted by:

INSTITUT PASTEUR

France