Objetivo The homeostatic control of lymphocyte numbers provides the immune system with a basic mechanism that shapes the repertoire of the immune-competent cells and therefore, the capacity to respond to exogenous antigens as well as to maintain self-tolerance. Homeostatic mechanisms will also enable the re-establishment of the immune system following disruption (irradiation or chemotherapy). During the process of restoration, the immune system can be reset at a new equilibrium overcoming any of its previous malfunctions. This capacity of homeostatic regulation may therefore be used in potential therapeutic strategies to radically modify lymphocyte repertoires, immune responses, autoimmune disease and allergy. We now postulate that control of lymphocyte numbers may be achieved by the ability of lymphocytes to perceive the density of their own populations. Lymphocytes may use quorum-sensing mechanisms to coordinate their gene expression according to the density of their population, as long as lymphocytes have (a) a mean of assessing the number of components they interact with and (b) a standard response once a threshold number of components is detected. To address the role of quorum-sensing in the Immune System this project aims: 1) To study the role of quorum-sensing mechanisms in the homeostasis of natural activated IgM-secreting and memory B cell populations, by studying the role of secreted IgG in these processes. 2) To determine the role of quorum-sensing mechanisms associated with the homeostasis of naïve and regulatory CD4+ T cells, by studying the role of IL-2 titers in T cell homeostasis. This project has a major potential impact in medical care, addresses new lines of research and uses original experimental strategies and models that we devised in the laboratory. Ámbito científico medical and health sciencesbasic medicineimmunologyautoimmune diseasesmedical and health sciencesclinical medicineallergologymedical and health sciencesbasic medicinephysiologyhomeostasis Programa(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) ERC-AG-LS6 - ERC Advanced Grant - Immunity and infection Convocatoria de propuestas ERC-2009-AdG Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-AG - ERC Advanced Grant Institución de acogida INSTITUT PASTEUR Aportación de la UE € 2 105 950,00 Dirección RUE DU DOCTEUR ROUX 25-28 75724 Paris Francia Ver en el mapa Región Ile-de-France Ile-de-France Paris Tipo de actividad Research Organisations Investigador principal Antonio Angelo Bastos Alves De Freitas (Prof.) Contacto administrativo Marie-Laure Rosso (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Beneficiarios (1) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo INSTITUT PASTEUR Francia Aportación de la UE € 2 105 950,00 Dirección RUE DU DOCTEUR ROUX 25-28 75724 Paris Ver en el mapa Región Ile-de-France Ile-de-France Paris Tipo de actividad Research Organisations Investigador principal Antonio Angelo Bastos Alves De Freitas (Prof.) Contacto administrativo Marie-Laure Rosso (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
