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European large-scale functional genomics in the rat for translational research

European large-scale functional genomics in the rat for translational research

Objective

Genetic studies in model organisms and humans, including human genome-wide association studies, have pinpointed genomic regions that contribute susceptibility to common disease. However, to date, these data have provided limited insights into the genes, molecular pathways and mechanisms underlying disease pathophysiology.

The EU FP6 Euratools consortium has been a remarkable success that established significant research collaborations, expertise and infrastructure in the EU, making a major contribution to the rat focus issue of Nature Genetics (Volume 40, May 2008), which featured six papers from the consortium. These successes underpin the current project in which we will use state-of-the-art and emerging large-scale technologies and advanced computation in an expanded multi-disciplinary approach to identify gene networks and genomic mechanisms underlying common diseases. We will use the rat as a model system to identify the major functional pathways underlying human inflammatory, cardiovascular and metabolic, and behavioral disorders.

Our consortium brings together world class investigators who will use next-generation sequencing technologies to generate genomic, transcriptomic and epigenomic datasets. To this, we will add cutting-edge, quantitative metabonomic and proteomic datasets to give significant depth of coverage, at multiple levels, across pathophysiological phenotypes. These datasets will be gathered, annotated and integrated in relational and dynamic models that will be used in comparative analyses to understand human gene function at the level of the molecule, cell, tissue and organism. These studies will lead to new insights into disease mechanisms, through an integrative, cross-disciplinary approach to understanding large-scale functional genomic datasets in rats and humans.

Coordinator

MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)

Address

Robert Rossle Strasse 10
13125 Berlin

Germany

Activity type

Research Organisations

EU Contribution

€ 1 980 000

Administrative Contact

Norbert Hubner (Prof.)

Participants (18)

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IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

EU Contribution

€ 1 612 000

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

EU Contribution

€ 438 500

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW

Netherlands

EU Contribution

€ 764 000

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

EU Contribution

€ 587 500

UNIVERSITY OF GLASGOW

United Kingdom

EU Contribution

€ 320 000

THE UNIVERSITY OF EDINBURGH

United Kingdom

EU Contribution

€ 325 000

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 497 500

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

EU Contribution

€ 641 500

FYZIOLOGICKY USTAV AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE (VVI)

Czechia

EU Contribution

€ 320 000

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

EU Contribution

€ 266 000

The Medical College of Wisconsin, Inc.

United States

EU Contribution

€ 255 000

National University Corporation, Kyoto University

Japan

EU Contribution

€ 155 000

RIJKSUNIVERSITEIT GRONINGEN

Netherlands

EU Contribution

€ 163 000

KUNGLIGA TEKNISKA HOEGSKOLAN

Sweden

EU Contribution

€ 140 000

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

EU Contribution

€ 600 500

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 320 000

KOBENHAVNS UNIVERSITET

Denmark

EU Contribution

€ 694 500

RESEARCH NETWORK SERVICES LIMITED

United Kingdom

EU Contribution

€ 420 000

Project information

Grant agreement ID: 241504

Status

Closed project

  • Start date

    1 April 2010

  • End date

    31 March 2015

Funded under:

FP7-HEALTH

  • Overall budget:

    € 13 695 674

  • EU contribution

    € 10 500 000

Coordinated by:

MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)

Germany