Mapping of Hepatitis C virus NS4B protein interactions with its host network

Ziel

Over 150 million individuals are infected with hepatitis C virus (HCV) worldwide. HCV is involved in chronic liver inflammation, fibrosis and formation of liver tumors. Similarly to other positive strand RNA viruses, HCV is believed to replicate its genome in association with cytoplasmic membranes. Nevertheless, the mechanisms of assembly and maintenance of the RNA replication complex as well as the mechanisms of cell transformation remain largely unknown. While previously characterized by a complete lack of known function, the HCV non-structural (NS) protein NS4B has emerged as the key player in the initiation of this critical process of membrane-associated complex assembly. We would like to map NS4B interaction with the human proteome. We hypothesize that some of the interactions discovered in this high-throughput screen will lead us to better understand the mechanism behind NS4B's role in HCV replication and cell transformation.

Wissenschaftliches Gebiet

Koordinator

BAR ILAN UNIVERSITY

EU-Beitrag

€ 100 000,00

Adresse

BAR ILAN UNIVERSITY CAMPUS
52900 Ramat Gan
Israel

Aktivitätstyp

Higher or Secondary Education Establishments

Kontakt Verwaltung

Estelle Waise (Ms.)

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Die Organisation kontaktieren Website

Gesamtkosten

Keine Daten

Ziel

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Programm/Programme

Thema/Themen

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Finanzierungsplan

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