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Self-learning modular manufacturing platform for flexible, patient-specific cell production

Objective

Personalized medicine (e.g. regenerative, such as cell therapy or patient-specific tested and composed pharmaceuticals) has huge potential. But to exploit this potential, it is necessary to produce human cells patient-specific in industrial scale. Nowadays, personalized cell production is only executed by means of manual processing on laboratory scale. In Order to make patient-specific production of cells available for a wide range of applications, CytoFab focuses on the development of an intelligent, modular manufacturing platform for flexible, patient-specific cell production which will increase efficiency of personalised cell production in quality and throughput. This objective will be reached by combining several high-sophisticated technologies such as a modular and scalable plug-in concept for the setup of cell production platforms, the application of a cleanroom and sterilisation concept to keep cell cultures cross-contamination free, a micro-fluidic component for customized cell culture medium composition, inline monitoring methodologies to enable the evaluation of cell status within the production process, and a manufacturing execution system which includes a self-learning knowledge-based cell behaviour and advanced cell process control fuctionalities for self-optimization of cell production processes. The latter is needed due to the individual nature of cells which makes it impossible, to process each cell with the same parameters without considerable variations in quality. With this high grade innovations, CytoFab will set a new standard in automated manufacturing technologies for personalized medicine applications.

Call for proposal

FP7-2010-NMP-ICT-FoF
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Coordinator

FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Address
Hansastrasse 27C
80686 Munchen
Germany
Activity type
Research Organisations
EU contribution
€ 930 460
Administrative Contact
Walter Krause (Mr.)

Participants (9)

MTA AUTOMATION AG

Participation ended

Switzerland
Address
Bernstrasse 5
3238 Gals
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Bruno Thomann (Mr.)
ABO AKADEMI
Finland
EU contribution
€ 350 962
Address
Domkyrkotorget 3
20500 Abo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
John E. Eriksson (Prof.)
PRIMACYT CELL CULTURE TECHNOLOGY GMBH
Germany
EU contribution
€ 115 312,40
Address
Hagenower Strasse 73
19061 Scherin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Dieter Runge (Dr.)
Chip-Man Technologies Oy
Finland
EU contribution
€ 488 737,60
Address
Biokatu 12
33520 Tampere
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jane Spencer-Fry (Dr.)
UNITECHNOLOGIES SA
Switzerland
EU contribution
€ 480 760
Address
Bernstrasse 5
3238 Gals
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Bruno Thomann (Mr.)
OSTBAYERISCHE TECHNISCHE HOCHSCHULE REGENSBURG
Germany
EU contribution
€ 291 700
Address
Prufeninger Strasse 58
93049 Regensburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thomas Schlegl (Prof.)
SZAMITASTECHNIKAI ES AUTOMATIZALASI KUTATOINTEZET
Hungary
EU contribution
€ 214 380
Address
Kende Utca 13-17
1111 Budapest
Activity type
Research Organisations
Administrative Contact
Geza Haidegger (Dr.)
ADVANCED CLEAN PRODUCTION INFORMATION TECHNOLOGY AKTIENGESELLSCHAFT
Germany
EU contribution
€ 311 970
Address
Handwerkstrasse 29
70565 Stuttgart
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Frank Frauenhoffer (Dr.)
AFT AUTOMATION UND FEINWERKTECHNIK GMBH
Germany
EU contribution
€ 251 418
Address
Carl Zeiss Strasse 4-6
75248 Olbronn Durrn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Wolfgang Bauer (Mr.)