CORDIS
EU research results

CORDIS

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Genetic and Epigenetic Networks in Cognitive Dysfunction

Project information

Grant agreement ID: 241995

Status

Closed project

  • Start date

    1 May 2010

  • End date

    30 April 2015

Funded under:

FP7-HEALTH

  • Overall budget:

    € 16 027 532,80

  • EU contribution

    € 11 647 068

Coordinated by:

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands

Objective

Mutations in about 400 different genes have been associated with Cognitive Disorders (CD), such as mental retardation, autism, neurodegenerative disorders, and psychiatric disorders. Whereas CD impose a major medical and socio-economical problem, there are no systematic studies that aim to provide insight into common mechanisms in CD. We propose a systems biology approach to gain insight into common mechanisms leading to cognitive impairment: (1) Identification of genes involved in cognitive disorders. Despite considerable progress in the identification of genes underlying CD, the majority of causative genes in CD remain unidentified. Therefore, our first objective is to identify new genes causative of CD by implementing high-throughput strategies. (2) Elucidation of molecular networks that are commonly disrupted in CD. Recent genetic and neurobiological research revealed evidence for a number of molecular and cellular pathways that are shared by the various genetic CDs. Prominent examples are Rho GTPase-related genes and genes that regulate chromatin structure/function (epigenetics) associated with mental retardation and autism. Our second objective is to systematically explore this concept by elucidation of molecular networks using functional genomics strategies in genetic models that are the cornerstone of neuroscience, such as mouse and fruit fly. (3) Identify genetic modifiers and small compounds that modulate the disease phenotype. Our third objective is to resolve the molecular underpinnings of the large degree of clinical variability that is typical for all types of CD, even among patients carrying identical gene mutations. Genetic modifier screens in cultured primary neurons as well as in available Drosophila models for CD will be used to reveal phenotypically relevant genetic interactions and molecular networks. Moreover, drug screens shall be conducted in fly and cellular models for CD, which will lead to pharmacological rescue of mouse models.

Coordinator

STICHTING KATHOLIEKE UNIVERSITEIT

Address

Geert Grooteplein Noord 9
6525 Ez Nijmegen

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 3 250 318

Administrative Contact

Wim Van Oijen (Mr.)

Participants (14)

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

EU Contribution

€ 1 838 220

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 1 186 600

University of Social Welfare and Rehabilitation Sciences; Genetics Research Center

Iran

EU Contribution

€ 281 200

GENOME RESEARCH LIMITED

United Kingdom

EU Contribution

€ 185 957,56

Synome Ltd

United Kingdom

EU Contribution

€ 366 400

FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH

Austria

EU Contribution

€ 667 000

MEDICAL RESEARCH COUNCIL

United Kingdom

EU Contribution

€ 353 016,91

CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE

France

EU Contribution

€ 1 095 100

Aktogen Limited

United Kingdom

EU Contribution

€ 687 100

European Genetic Alliance Network

Belgium

LAHORE MEDICAL COLLEGE - ALLAMA IQBAL MEDICAL COLLEGE

Pakistan

EU Contribution

€ 265 000

THE UNIVERSITY OF EDINBURGH

United Kingdom

EU Contribution

€ 1 087 942,44

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

EU Contribution

€ 268 113,09

VERENIGING SAMENWERKENDE OUDER- EN PATIENTENORGANISATIES

Netherlands

EU Contribution

€ 115 100

Project information

Grant agreement ID: 241995

Status

Closed project

  • Start date

    1 May 2010

  • End date

    30 April 2015

Funded under:

FP7-HEALTH

  • Overall budget:

    € 16 027 532,80

  • EU contribution

    € 11 647 068

Coordinated by:

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands