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Genetic and Epigenetic Networks in Cognitive Dysfunction

Objective

Mutations in about 400 different genes have been associated with Cognitive Disorders (CD), such as mental retardation, autism, neurodegenerative disorders, and psychiatric disorders. Whereas CD impose a major medical and socio-economical problem, there are no systematic studies that aim to provide insight into common mechanisms in CD. We propose a systems biology approach to gain insight into common mechanisms leading to cognitive impairment: (1) Identification of genes involved in cognitive disorders. Despite considerable progress in the identification of genes underlying CD, the majority of causative genes in CD remain unidentified. Therefore, our first objective is to identify new genes causative of CD by implementing high-throughput strategies. (2) Elucidation of molecular networks that are commonly disrupted in CD. Recent genetic and neurobiological research revealed evidence for a number of molecular and cellular pathways that are shared by the various genetic CDs. Prominent examples are Rho GTPase-related genes and genes that regulate chromatin structure/function (epigenetics) associated with mental retardation and autism. Our second objective is to systematically explore this concept by elucidation of molecular networks using functional genomics strategies in genetic models that are the cornerstone of neuroscience, such as mouse and fruit fly. (3) Identify genetic modifiers and small compounds that modulate the disease phenotype. Our third objective is to resolve the molecular underpinnings of the large degree of clinical variability that is typical for all types of CD, even among patients carrying identical gene mutations. Genetic modifier screens in cultured primary neurons as well as in available Drosophila models for CD will be used to reveal phenotypically relevant genetic interactions and molecular networks. Moreover, drug screens shall be conducted in fly and cellular models for CD, which will lead to pharmacological rescue of mouse models.

Call for proposal

FP7-HEALTH-2009-two-stage
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Coordinator

STICHTING RADBOUD UNIVERSITEIT
Address
Houtlaan 4
6525 XZ Nijmegen
Netherlands

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wim Van Oijen (Mr.)
EU contribution
€ 3 250 318

Participants (14)

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 1 838 220
Address
Hofgartenstrasse 8
80539 Munchen

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Activity type
Research Organisations
Administrative Contact
Anke Badrow (Ms.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 1 186 600
Address
Rue De Tolbiac 101
75654 Paris

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Activity type
Research Organisations
Administrative Contact
Annick Bertault (Ms.)
University of Social Welfare and Rehabilitation Sciences; Genetics Research Center
Iran
EU contribution
€ 281 200
Address
Daneshjoo Blvd, Koodakyar St, Evin
1985713831 Tehran

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Hossein Najmabadi (Prof.)
GENOME RESEARCH LIMITED

Participation ended

United Kingdom
EU contribution
€ 185 957,56
Address
The Gibbs Building, Euston Road 215
NW1 2BE London

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Activity type
Research Organisations
Administrative Contact
David Davison (Mr.)
Synome Ltd
United Kingdom
EU contribution
€ 366 400
Address
Moneta Building Babraham Research Campus
CB4 1GU Cambridge

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Troels Jordansen (Mr.)
FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH
Austria
EU contribution
€ 667 000
Address
Campus-vienna-biocenter 1
1030 Wien

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Tanja Winkler (Ms.)
MEDICAL RESEARCH COUNCIL

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United Kingdom
EU contribution
€ 353 016,91
Address
20 Park Crescent
W1B 1AL London

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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Claire Bloomfield (Dr.)
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
France
EU contribution
€ 1 095 100
Address
Rue Laurent Fries 1
67404 Illkirch Graffenstaden

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Activity type
Research Organisations
Administrative Contact
Steve Brooks (Dr.)
Aktogen Limited
United Kingdom
EU contribution
€ 687 100
Address
Gilbert Road 72
CB4 3PD Cambridge

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Zoltan Asztalos (Dr.)
European Genetic Alliance Network

Participation ended

Belgium
Address
Avenue Louise
1050 Brussels

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Cor Oosterwijk (Dr.)
LAHORE MEDICAL COLLEGE - ALLAMA IQBAL MEDICAL COLLEGE
Pakistan
EU contribution
€ 265 000
Address
Allama Shabbir Ahmad Usmani Road
54550 Lahore 20

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Shamsul Haq (Mr.)
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 1 087 942,44
Address
Old College, South Bridge
EH8 9YL Edinburgh

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Angela Noble (Ms.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 268 113,09
Address
Wellington Square University Offices
OX1 2JD Oxford

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gill Wells (Ms.)
VERENIGING SAMENWERKENDE OUDER- EN PATIENTENORGANISATIES
Netherlands
EU contribution
€ 115 100
Address
Vredehofstraat 31
3761HA Soest

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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Marijke Bouma (Mrs.)