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Active wound dressings based on biological mimicry

Objective

The aim of the Bacteriosafe consortium is to construct, test and develop a unique active wound dressing, which incorporates novel colourimetric sensor and active therapeutic processes for detecting and counteracting pathogenic bacteria in wounds. The inspiration for this project is the natural nano-biological mechanism of bacterial attack on healthy cells. The outer cell walls are ruptured by an array of protein toxins, lipases and other enzymes secreted by these bacteria. We mimic this natural process by using these pathogenic factors to liberate engineered and biologically derived antibiotics/antimicrobials and indicating molecules from highly designed surface immobilized nanocapsules. This will minimize the need for frequent traumatic changes of wound dressing and will provide a simple optical indicator of bacterial infection. In addition to a significant cost reduction, the proposed dressing will minimize the time required for the analysis of bacterial infection. This is particularly critical in burn wounds where delayed detection of bacterial infection can result in patient death. The project will cover both the research into the basic mechanisms of device operation, the development of a prototype device and the process engineering which is necessary to prepare it for large scale industrial production.

Field of science

  • /natural sciences/biological sciences/microbiology/bacteriology
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/enzymes

Call for proposal

FP7-NMP-2009-SMALL-3
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Address
Hofgartenstrasse 8
80539 Munich
Germany
Activity type
Other
EU contribution
€ 1 037 000
Administrative Contact
Udo Schreiner (Mr.)

Participants (10)

UNIVERSITY OF BATH
United Kingdom
EU contribution
€ 748 000
Address
Claverton Down
BA2 7AY Bath
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Hazel Wallis (Ms.)
UNIVERSITAET SIEGEN
Germany
EU contribution
€ 357 000
Address
Adolf Reichwein Strasse 2A
57076 Siegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katja Bieler
LAPPEENRANNAN-LAHDEN TEKNILLINEN YLIOPISTO LUT
Finland
EU contribution
€ 429 000
Address
Yliopistonkatu 34
53850 Lappeenranta
Activity type
Higher or Secondary Education Establishments
Administrative Contact
David Cameron (Prof.)
UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
Germany
EU contribution
€ 363 200
Address
Langenbeckstrasse 1
55131 Mainz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nicole Metz (Ms.)
DUBLIN CITY UNIVERSITY
Ireland
EU contribution
€ 363 000
Address
Glasnevin
9 Dublin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Martin Clynes (Prof.)
CENTRE SCIENTIFIQUE & TECHNIQUE DEL'INDUSTRIE TEXTILE BELGE ASBL
Belgium
EU contribution
€ 147 000
Address
Rue Montoyer 24/2
1000 Bruxelles
Activity type
Research Organisations
Administrative Contact
Guy Buyle (Dr.)
NORTH BRISTOL NATIONAL HEALTH SERVICE TRUST
United Kingdom
Address
Southmead Hospital, Southmead Road, Westbury On Trym
BS10 5NB Bristol
Activity type
Research Organisations
Administrative Contact
Amber Young (Dr.)
PAUL HARTMANN AG.
Germany
Address
Paul-hartmann-straße 12
89522 Heidenheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Peter Hietkamp (Mr.)
FREUDENBERG PERFORMANCE MATERIALS SE & CO KG
Germany
Address
Hohnerweg 2-4
69469 Weinheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Bernd Schlesselmann (Dr.)
UNIVERSITY OF SOUTH AUSTRALIA
Australia
Address
North Terrace
5000 Adelaide
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mark Hochmann (Dr.)