Objective B cells are responsible for the humoral arm of the immune response and most successfulvaccines in humans are antibody-based. Depending on the pathogen, specific B cell subsets aremobilized and a variety of innate, intermediate or adaptive responses are produced. In somecases these responses generate memory in anticipation of a re-encounter with the same pathogen.B cells can also present antigens to T cells, and enhance or suppress immune responses,depending in which T cell context they are primed.The present project aims to describe new innate-like and memory B cell subsets and tounravel the molecular switch allowing the differentiation and the long-term maintenanceinto the memory program. This will be done by combining approaches in both humans andmice, in order to reveal the analogies and the differences between these two immunesystems.Our main specific aims are 1) to establish a reporter cell line that, by complementation with acDNA library from human centrocytes and memory B cells, should allow the identification of amaster gene able to trigger the memory program 2) to compare various antigenic andendogenous stimuli in terms of formation of various innate-like and memory subsets, using amouse model that, by marking irreversibly B cells during an immune response, has allowed us toreveal new layers of B-cell memory 3) to study the endogenous and exogenous signals thatsupport the development of marginal zone B cells in humans 4) to unravel the genes that governlong-term B cell memory, by isolating anti-vaccinia virus long-lived human memory B cells. Thegeneral ambition is to provide new insights into the complexity of the B cell compartment thatshould allow the improvement of B-cell targeted vaccination strategies. Fields of science natural sciencesbiological sciencesmicrobiologyvirologymedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-AG-LS6 - ERC Advanced Grant - Immunity and infection Call for proposal ERC-2009-AdG See other projects for this call Funding Scheme ERC-AG - ERC Advanced Grant Host institution INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE EU contribution € 1 695 980,00 Address RUE DE TOLBIAC 101 75654 Paris France See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Nicolas Jeanjean (Mr.) Principal investigator Jean-Claude Weill (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Beneficiaries (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 1 695 980,00 Address RUE DE TOLBIAC 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Nicolas Jeanjean (Mr.) Principal investigator Jean-Claude Weill (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data