Development of molecules for the stabilization of quadruplex DNA and regulation of oncogene expression: a potential route to novel anticancer drugs

Projektinformationen

DMSQD

ID Finanzhilfevereinbarung: 251761

Abgeschlossenes Projekt

Startdatum 1 Januar 2011

Enddatum 31 Dezember 2012

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 172 240,80

EU-Beitrag € 172 240,80

Koordiniert durch

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom

Ziel

In this project we aim to develop a series of metal-containing molecules with the ability to interact with specific DNA sequences. More specifically, we will target what is called quadruplex DNA. It has been recently identified that there are approximately 350,000 sequences in the human genome that can potentially form quadruplex DNA structures. More interestingly, some of these regions have already been identified as potential targets for the development of cancer drugs. Therefore, we will aim to develop metal complexes that can selectively interact with these specific quadruplex DNA structures. The project will involve the design (aided by computational methods), development and characterisation of the new molecules. The DNA binding properties of these molecules will be evaluated using a range of techniques (e.g. FRET, FID, SPR and CD). This will allow us to identify lead molecules (those that interact more strongly and selectively with specific quadruplex DNA structures) so that their biological activity can be evaluated.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › genetics › DNA
• natural sciences › computer and information sciences › computational science
• medical and health sciences › clinical medicine › oncology
• natural sciences › biological sciences › genetics › genomes

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2009-IEF - Marie Curie Action: "Intra-European Fellowships for Career Development"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2009-IEF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IEF - Intra-European Fellowships (IEF)

Koordinator

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

Kontakt Verwaltung

Brooke Alasya (Ms.)

• EU-Beitrag: € 172 240,80
• Adresse: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD ; SW7 2AZ LONDON ; Vereinigtes Königreich
• Region: London › Inner London — West › Westminster
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten