CORDIS
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CORDIS

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Catalytic and mechanistic studies of Organometallic reactions in water: focus on alkylation processes

Project information

Grant agreement ID: 252531

Status

Closed project

  • Start date

    1 June 2010

  • End date

    31 May 2012

Funded under:

FP7-PEOPLE

  • Overall budget:

    € 172 740,80

  • EU contribution

    € 172 740,80

Coordinated by:

UNIVERSITY OF BRISTOL

United Kingdom

Objective

Recently, concerns over hazardous waste generated during catalytic reactions and separation of products from catalyst increasingly led to the development of systems that employ water as solvent. An understanding of the specific mechanisms in water is required, however, for a rational optimization of processes. Pd-catalyzed allylation has played a major role in the evolution of synthetic catalysts for asymmetric C-C bond-forming reactions in organic solvent. However, whilst ligands are exceptionally selective, its mode of asymmetric induction has remained very much a 'black-box'. We propose to exploit the key interactions and how water could change the critical step of the reaction in classical organic solvents. Through the systematic study of structure-selectivity relationships, single crystal X-ray analysis, NMR spectroscopy of intermediates and Kinetic studies, the Fellow will study the asymmetric allylic alkylation reactions in aqueous medium, acquiring new competencies in the areas of physical organic chemistry, mechanistic aspects of catalysis, isotopic labelling, high field multinuclear (dynamic) NMR, and reaction kinetics. We will study as the enantioselectivity of asymmetric carbonylations could be controlled. Moreover, we want to understand the different behaviour of Pt catalyst in allylation reaction. Undertaking the project at the Community level will be very beneficial in three senses. Firstly, research and publications in mechanistic and synthetic aspects of asymmetric catalysis will strongly raise the profile of an area in which Europe lags substantially behind, as compared to the USA and Japan; secondly it will ensure that the Fellow's skills in aqueous chemistry will be retained in Europe and will be transferred to the host group. Finally, an excellent postdoctoral experience in a prime European university will actively encourage the Fellow to stay within Europe upon completion.
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Coordinator

UNIVERSITY OF BRISTOL

Address

Beacon House Queens Road
Bs8 1qu Bristol

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 172 740,80

Administrative Contact

Johanna Rule (Ms.)

Project information

Grant agreement ID: 252531

Status

Closed project

  • Start date

    1 June 2010

  • End date

    31 May 2012

Funded under:

FP7-PEOPLE

  • Overall budget:

    € 172 740,80

  • EU contribution

    € 172 740,80

Coordinated by:

UNIVERSITY OF BRISTOL

United Kingdom