Objective Osteoarthritis (OA) is the most common disease of the joints. However, the molecular mechanisms that are involved in its pathogenesis are still unclear. One of the major causes of OA is obesity. The past few years a lot of studies have focused on the functional link between adipose tissue and cartilage in the development of OA. It has been recently shown that apolipoprotein E (apoE) over-expression promotes diet-induced obesity in mice. In addition, in vitro studies have demonstrated that apoE gene deficiency enhances the reduction of bone in mice fed high-fat diet, while lack of ApoE leads to increased bone formation in mice fed chaw diet. Triggered by these findings, in the present proposal the applicant will use in vivo, biochemical and molecular methodologies in order to investigate the role of ApoE in the pathobiology of obesity-induced OA in mice and explore its implication in the development and progression of OA in humans. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculeslipidsmedical and health scienceshealth sciencesnutritionobesity Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2009-RG - Marie Curie Action: "Reintegration Grants" Call for proposal FP7-PEOPLE-2009-RG See other projects for this call Funding Scheme MC-IRG - International Re-integration Grants (IRG) Coordinator PANEPISTIMIO PATRON EU contribution € 100 000,00 Address UNIVERSITY CAMPUS RIO PATRAS 265 04 Rio Patras Greece See on map Region Κεντρική Ελλάδα Δυτική Ελλάδα Αχαΐα Activity type Higher or Secondary Education Establishments Administrative Contact Natassa Kapatsoulia (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
