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European project on the characterisation of transgenic rat models for neurodegenerative and psychiatric diseases: Automated home cage analyses, live imaging and treatment

European project on the characterisation of transgenic rat models for neurodegenerative and psychiatric diseases: Automated home cage analyses, live imaging and treatment

Objective

The RATstream' consortium will concentrate on the comprehensive phenotypical characterization of rat models of neurodegenerative diseases such as Huntington's disease (HD), Parkinson's disease (PD) and spinocerebellar ataxia type 17 (SCA17). Ultimately, the project will deliver a procedure for low cost automated drug screening along with a set of data describing the phenotype for each of the models. To achieve this goal, automated home cage systems for behavioural and physiological phenotyping will be developed by two SMEs and validated independently by two academic partners and individual data will be incorporated into an integrated database developed by a third SME.

In a joint effort the groups will develop a comprehensive set of behavioural and physiological phenotyping procedures including PET and DTI technologies to systematically detect neuropsychiatric correlates of neuronal dysfunction and disease progression in rat models of HD, PD, and SCA17.

The resulting set of biomarkers will lead to a valid set of minimised experiments and markers best suited to provide read-out parameters in pre-clinical studies applying novel substances delaying or preventing neurodegeneration.'

Coordinator

EBERHARD-KARLS UNIVERSITÄT TUEBINGEN

Address

Wilhelmstr. 7
TÜBingen

Germany

Administrative Contact

Olaf RIESS (Prof.)

Participants (7)

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NEWBEHAVIOR AG

Switzerland

TSE SYSTEMS GMBH

Germany

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

CROSSLINKS BV

Netherlands

UNIVERSTITEIT ANTWERPEN

Belgium

FRIEDRICH-ALEXANDER UNIVERSITÄT ERLANGEN-NÜRNBERG

Germany

TROPHOS SA

France

Project information

Grant agreement ID: 37846

  • Start date

    1 January 2007

  • End date

    30 June 2010

Funded under:

FP6-IST

  • Overall budget:

    € 4 965 801

  • EU contribution

    € 3 400 000

Coordinated by:

EBERHARD-KARLS UNIVERSITÄT TUEBINGEN

Germany