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Platform for Advanced Single Cell-Manipulation and Analysis

Platform for Advanced Single Cell-Manipulation and Analysis

Objective

Analysis of biological cells down to single cell resolution is a prospective technique in nearly all fields of life science research. In particular manipulation and analysis of single cells can open up a new dimension in cell biology, tissue engineering, drug development and diagnostics. The advancement of single cell technology as a whole requires tools and instrumentation to sort, transport and manipulate single living cells. Micro system technology with its sophistications can provide in this context capabilities far beyond today's methods.
Therefore, this project aims to develop a single cell manipulator (SCM) micro instrument for inkjet like printing of single living cells confined in micro droplets of only 50µm size. Such a device can serve as a universal tool for manipulating cells in a non-invasive flexible manner. Within the project the SCM device will be applied to cell biological applications in cancer research and drug development to demonstrate and validate the performance of the device, as well as to establish a flexible platform for advanced single cell-manipulation and analysis (PASCA).
In order to achieve these objectives crosscutting technological challenges have to be faced which can be overcome by integrating and interfacing multiple core technologies, only. Cutting edge bio-sensing technology like impedance spectroscopy and state of the art micro dispensing methods will be applied and combined with latest cell biological methods to establish the SCM instrument as multifunctional microsystem for cell manipulation. Through the highly innovative integrated approach and the validation within the PASCA platform the SCM instrument has excellent exploitation perspectives in multiple application sectors.
Also the project structure as a whole supports the objectives of the work program:By intensively involving SMEs to feed the innovation cycle and by bringing the user into research cycles through the open access partner structure.

Coordinator

ALBERT-LUDWIGS-UNIVERSITAET FREIBURG

Address

Fahnenbergplatz
79098 Freiburg

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 804 731

Administrative Contact

Melanie Baumann (Ms.)

Participants (6)

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ZURICH INSTRUMENTS AG

Switzerland

EU Contribution

€ 380 020

BIOFLUIDIX GMBH

Germany

EU Contribution

€ 317 924

SOPHION BIOSCIENCE A/S

Denmark

EU Contribution

€ 363 258

Innovative Technologies in Biological Systems

Spain

EU Contribution

€ 286 360

Primadiag SAS

France

EU Contribution

€ 321 987

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN

Ireland

EU Contribution

€ 525 720

Project information

Grant agreement ID: 257073

Status

Closed project

  • Start date

    1 September 2010

  • End date

    31 December 2013

Funded under:

FP7-ICT

  • Overall budget:

    € 3 935 225

  • EU contribution

    € 3 000 000

Coordinated by:

ALBERT-LUDWIGS-UNIVERSITAET FREIBURG

Germany