Cel The hygiene hypothesis postulating the paradoxical protective role of infections on immune-mediateddiseases including atopy (i.e. atopic dermatitis, rhinitis, asthma) and more recently autoimmune diseases hasbeen the matter of extensive investigation. The aim of the present project is to validate this hypothesisintegrating epidemiological and experimental studies.We will review in a meta-analysis published studies of direct and indirect markers of infections and atopicdiseases, and conduct a case-control study to analyse the association between infections and atopy usingatopic dermatitis as a prototypic model. This epidemiological study will assess the occurrence of differentinfections and other risk factors related to the incidence of atopic dermatitis in children under age five inItaly (300 cases and 600 controls).This epidemiological study will be supported by experimental approaches addressing mechanistic questionsraised by the hygiene hypothesis. Experimental models will include induction of acute and chronicbronchoconstriction/asthma, atopic dermatitis. In addition the project will aim at devising new mouse modelsof atopy. The nature of infections providing protection against allergic diseases will be investigated tocharacterise the difference at the molecular level between protective and non protective pathogens or theirderivatives. The underlying immune mechanisms notably homeostasis imbalance, antigenic competition,stimulation of regulatory immune cells and Toll-like receptor involvement will be analysed. In addition todeveloping integrated in vivo models, including the use of transgenic animals, efforts will be focussed on thestudy of available synthetic pathogen-derived compounds showing a protective activity to better approachtheir cellular and molecular mode of action. These studies may pave the way to novel and safe therapies thatcould advantageously substitute for the “protective” immune stimulation induced by major infections. Dziedzina nauki medical and health sciencesclinical medicinepneumologyasthmamedical and health scienceshealth sciencespublic healthepidemiologymedical and health sciencesbasic medicineimmunologyautoimmune diseasesmedical and health sciencesbasic medicinephysiologyhomeostasis Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-AG-LS7 - ERC Advanced Grant - Diagnostic tools, therapies and public health Zaproszenie do składania wniosków ERC-2009-AdG Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-AG - ERC Advanced Grant Instytucja przyjmująca INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Wkład UE € 1 098 320,00 Adres RUE DE TOLBIAC 101 75654 Paris Francja Zobacz na mapie Region Ile-de-France Ile-de-France Paris Rodzaj działalności Research Organisations Kierownik naukowy Jean-François Bach (Prof.) Kontakt administracyjny Téva West (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Beneficjenci (2) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Francja Wkład UE € 1 098 320,00 Adres RUE DE TOLBIAC 101 75654 Paris Zobacz na mapie Region Ile-de-France Ile-de-France Paris Rodzaj działalności Research Organisations Kierownik naukowy Jean-François Bach (Prof.) Kontakt administracyjny Téva West (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI Włochy Wkład UE € 1 001 679,00 Adres VIA MARIO NEGRI 2 20156 Milano Zobacz na mapie Region Nord-Ovest Lombardia Milano Rodzaj działalności Research Organisations Kontakt administracyjny Maria Grazia Pezzoni (Ms.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
