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Systems Biology of Mitosis

Objective

"MitoSys will generate a comprehensive mathematical understanding of mitotic division in human cells, a process of fundamental importance for human health. To create the critical mass and multidisciplinarity that is needed to achieve this ambitious goal, internationally leading mathematicians, biochemists/biophysicists and biologists working at twelve universities, research institutes, international organizations and companies in eight different European countries will collaborate. Mathematicians will focus on four biological modules that represent the most important aspects of the mitotic cell division process; (i) spindle assembly, (ii) the spindle assembly checkpoint and kinetochores, (iii) segregation of mitotic chromosomes and (iv) mitotic exit. Computational models of these separate modules will be integrated into a comprehensive model of mitosis that combines these steps of mitosis with regulation by protein kinases and ubiquitin ligases. To be able to achieve these tasks, the modellers will be supported by biologists and physicists who will use microscopic imaging, biochemistry, biophysics, single-molecule techniques and proteomics to generate kinetic and other quantitative data suitable for model building. To evaluate the relevance of the mathematical models for human health and disease, other biologists will subject selected key predictions from these models to rigorous in-vivo tests by using conditional ""knock-out"" mice. MitoSys will compile and disseminate its own data and models, but also datasets from public sources, in a web-database, which will serve as a systems biology resource for the scientific community. To train other scientists in systems biology, MitoSys will organize a practical workshop on mathematical modelling. Finally, MitoSys will inform the general public about systems biology of mitosis and its relevance to health and disease by organizing an exhibition, which will be displayed in several European cities."

Field of science

  • /natural sciences/biological sciences/genetics and heredity/chromosome
  • /natural sciences/mathematics/applied mathematics/mathematical model
  • /natural sciences/biological sciences/biophysics
  • /natural sciences/biological sciences/biochemistry
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics

Call for proposal

FP7-HEALTH-2009-two-stage
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH
Address
Campus-vienna-biocenter 1
1030 Wien
Austria
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 1 563 265,81
Administrative Contact
Yan Sun (Dr.)

Participants (13)

EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 1 375 434
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
Administrative Contact
Phil Irving (Dr.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 979 245
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Pocklington Gerry (Prof.)
INSTITUT CURIE
France
EU contribution
€ 500 800
Address
Rue D'ulm 26
75231 Paris
Activity type
Research Organisations
Administrative Contact
Jean-Francois Joanny (Prof.)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 2 377 523
Address
Hofgartenstrasse 8
80539 Munich
Activity type
Other
Administrative Contact
Birgit Knepper-Nicolai (Dr.)
ISTITUTO EUROPEO DI ONCOLOGIA SRL

Participation ended

Italy
EU contribution
€ 164 297
Address
Via Filodrammatici 10
20121 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ilaria Foti (Ms.)
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Participation ended

Switzerland
EU contribution
€ 90 311,93
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Daniel Wolfram Gerlich (Prof.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 554 273
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Michèle Saumon (Dr.)
FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III
Spain
EU contribution
€ 525 605
Address
Calle Melchor Fernandez Almagro 3
28029 Madrid
Activity type
Research Organisations
Administrative Contact
Dolores Liébanes (Ms.)
TECHNISCHE UNIVERSITEIT DELFT
Netherlands
EU contribution
€ 555 581
Address
Stevinweg 1
2628 CN Delft
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jose Van Vugt (Ms.)
MEDICAL RESEARCH COUNCIL
United Kingdom
EU contribution
€ 275 900
Address
North Star Avenue Polaris House 2 Floor David Phillips Building
SN2 1FL Swindon
Activity type
Research Organisations
Administrative Contact
Elizabeth Cutler (Ms.)
CARL ZEISS MICROSCOPY GMBH
Germany
EU contribution
€ 452 491
Address
Carl Zeiss Promenade 10
07745 Jena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ralf Wolleschensky (Mr.)
THE UNIVERSITY OF THE ARTS LONDON
United Kingdom
EU contribution
€ 320 826,19
Address
272 High Holburn
WC1V 7EY London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dani Salvadori (Ms.)
INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH
Austria
EU contribution
€ 462 688,07
Address
Dr Bohrgasse 3
1030 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Tanja Winkler (Ms.)