There is a limited understanding of critical oncogenes and oncosuppressors of human brain tumors, which are often lethal within monthly frames. In order to better understand brain tumor homeostasis, we aim to apply unbiased functional genomics and synthetic lethality screenings to a mouse models of Glioma, and to validate such screenings using human Glioma cell lines. On the long term, this study may provide more effective prognostic factors and pharmacological targets for brain cancer treatment.