Cel The target of this proposal is ageing and its association with reproduction, immunity and behaviour. This is an area of biology that has intrigued every generation since Aristotle (c. 300 BC). We assess how free radicals (reactive oxygen species), so often identified as factors of ageing and immune disorders, exert selection on living organisms and whether resistance (and defence) towards free radicals may drive evolution of ageing in the wild. In particular, we study (i) how free radicals, the defence systems associated with them and the reproductive and the immune system interact to shape life history trade-offs, (ii) how free radicals impact on survival in the wild and, (iii) how epigenetic factors such as maternal hormones contribute to the formation of behavioural phenotypes (personalities) with different free radical profiles. This project integrates field studies and laboratory experiments using two uniquely suited model species (the Australian Painted dragon lizard and the zebra finch) and combines them with state-of-the-art molecular techniques to investigate variation in free radical production and defences. In spite of excellent work in the laboratory, this is one of the first attempts to study free radicals in the 'real world' and will extend Europe’s excellent reputation in evolutionary biology. Dziedzina nauki humanitieshistory and archaeologyhistorynatural sciencesbiological sciencesevolutionary biologymedical and health sciencesbasic medicineimmunology Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2009-IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development" Zaproszenie do składania wniosków FP7-PEOPLE-2009-IOF Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-IOF - International Outgoing Fellowships (IOF) Koordynator MAX IV Laboratory, Lund University Wkład UE € 275 525,90 Adres Paradisgatan 5c 22100 LUND Szwecja Zobacz na mapie Region Södra Sverige Sydsverige Skåne län Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Dennis Hasselquist (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
