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COMPOSITE PHENOTYPIC TRIGGERS FOR BONE AND CARTILAGE REPAIR

Objective

Osteoarthritis (OA) and osteoporosis (OP) are disabling, degenerative bone diseases with significant economic and societal impacts. The incidence of these conditions increases with age but in recent years the number of younger patients has increased, due mainly to factors related to modern life-styles. The efficiency of current pharmacologic and implant-based solutions are limited and often poorly tolerated. OPHIS aims to develop new, engineered biomaterials for the regeneration of both the osteo-chondral region and the vertebral body degenerated by OA and OP. These devices will be based on the unique combination of biological triggers in the form of (i) nanostructured biomaterials able to mimic the extracellular matrices of either bone or cartilage (ii) chemical and biochemical cues able to direct, control and preserve the phenotypes of the relevant cells in their respective histological compartments. OPHIS will explore the frontiers of knowledge of the effect of nano-structures on tissue regeneration and lead to the de-novo design of active structures able to trigger this process. User friendly and highly performing tissue substitutes will be developed as both acellular and cellular matrices for the regeneration of specific anatomical regions compromised by OA and OP. Focus will also be given to the study of the interactions occurring at nano-scale level between the implanted materials and the natural tissues. This information will complement the body of data obtained through clinically reflective in vitro and in vivo models. Dissemination will be integrated step-wise with the strategy for intellectual property protection and exploitation.

Call for proposal

FP7-NMP-2009-SMALL-3
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Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE
Address
Piazzale Aldo Moro 7
00185 Roma
Italy

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Activity type
Research Organisations
Administrative Contact
Anna Tampieri (Dr.)
EU contribution
€ 704 366

Participants (8)

FRIEDRICH-SCHILLER-UNIVERSITAT JENA
Germany
EU contribution
€ 346 160
Address
Furstengraben 1
07743 Jena

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Mueller (Prof.)
UNIVERSITY OF BRIGHTON
United Kingdom
EU contribution
€ 468 000
Address
Lewes Road Mithras House
BN2 4AT Brighton

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Matteo Santin (Dr.)
UNIVERSITATSSPITAL BASEL
Switzerland
EU contribution
€ 515 000
Address
Hebelstrasse 32
4031 Basel

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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Ivan Martin (Prof.)
FIN-CERAMICA FAENZA SPA
Italy
EU contribution
€ 465 000
Address
Via Granarolo 177/3
48018 Faenza

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Roberta Martinetti (Dr.)
TECHNISCHE UNIVERSITAET DRESDEN
Germany
EU contribution
€ 357 480
Address
Helmholtzstrasse 10
01069 Dresden

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michael Gelinsky (Dr.)
ISTITUTO ORTOPEDICO RIZZOLI
Italy
EU contribution
€ 413 597
Address
Via Di Barbiano 1/10
40136 Bologna

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Activity type
Research Organisations
Administrative Contact
Maurilio Marcacci (Prof.)
LABORATOIRE D'EVALUTION DES MATERIELS IMPLANTABLES SA
France
EU contribution
€ 251 065
Address
Technopole Bordeaux-montesquieu, Allée François Magendie 2
33650 Martillac

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marie-Françoise Harmand (Dr.)
UNIVERSITA CATTOLICA DEL SACRO CUORE
Italy
EU contribution
€ 419 040
Address
Largo Gemelli 1
20123 Milano

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Giandomenico Logroscino (Prof.)