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Selective Antibodies Limited Immuno Assay Novel Technology

Objective

SALIANT aims to develop a hand-held device for real-time analysis of trace levels of explosives, chemicals and drugs. The key innovation is a positive detection lateral-flow test for small molecules that is highly sensitive and simple to use making it ideally suited to deployment by First Responders at crime scenes and terrorist incidents. Lateral flow immunodiagnostics has long offered the promise of fast, high quality testing for substances of low molecular weight. There have however been very real challenges to bringing the full power of such technology to bear in this area. The problem is simply size. Large analytes can support the simultaneous binding of both capture and detector antibodies, allowing typical excess-reagent sandwich immunoassays to be formatted in which increasing analyte concentration provides an increase of observable signal over a very low zero background. Small molecules are simply not large enough to support such simultaneous binding. Alternative systems in effect measure how much analyte is not present. This causes major problems in terms of precision, sensitivity and read-out where, classically, increasing concentration of analyte reduces the signal produced, making point-of-need devices often difficult to read. What is required is a robust system in which there is no observable signal in the absence of analyte, and even low level samples give an obvious observable signal over this zero background. SALIANT offers a system based on a small bindable moiety that is first conjugated close to the binding site of a primary antibody against the analyte such that when analyte binds the antibody, the moiety can still be bound by a labelled secondary antibody. A large reagent-analogue of the analyte is also introduced, binding analyte-unbound primary antibody, and thereby blocking binding of the secondary antibody to the moiety. Thus the more analyte present, the more binding of secondary antibody occurs and the more signal is produced.

Call for proposal

FP7-SEC-2009-1
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Coordinator

UNIVERSITY OF NEWCASTLE UPON TYNE
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne
United Kingdom

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Helen Gallon (Ms.)
EU contribution
€ 66 443,60

Participants (10)

Selective Antibodies Limited
United Kingdom
EU contribution
€ 1 184 563,20
Address
Cels At Newcastle William Leech Building Framlington Place
NE2 4HH Newcastle Upon Tyne

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Colin Self (Prof.)
OY REAGENA Ltd
Finland
EU contribution
€ 330 534,55
Address
Takojantie 18
70900 Toivala

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Markku Tuomo Olavi Parviainen (Dr.)
Indicia Biotechnology
France
EU contribution
€ 619 680
Address
Avenue De La Californie 33
69600 Oullins

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Stephane Legastelois (Dr.)
Department of Justice, Equality & Law Reform
Ireland
EU contribution
€ 44 714,40
Address
St. Stephen's Green 94
Dublin 2 Dublin

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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Catriona Rainsford (Ms.)
ZILINSKA UNIVERZITA V ZILINE
Slovakia
EU contribution
€ 134 495,60
Address
Univerzitna 8215/1
010 26 Zilina

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ladislav šimák (Prof.)
Netherlands Forensic Institute
Netherlands
EU contribution
€ 177 641,25
Address
Laan Van Ypenburg 6
2490 AA The Hague

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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Marcel Van Der Steen (Mr.)
METROHM-APPLIKON
Netherlands
EU contribution
€ 155 760
Address
De Brauwweg 13
3125AE Schiedam

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Timeor Frelink (Dr.)
STICHTING WAGENINGEN RESEARCH
Netherlands
EU contribution
€ 407 726
Address
Droevendaalsesteeg 4
6708 PB Wageningen

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Activity type
Research Organisations
Administrative Contact
Ruben Van Deursen (Mr.)
CENTRE OF EXCELLENCE FOR LIFE SCIENCES LTD
United Kingdom
EU contribution
€ 110 640
Address
Quorum 16
NE12 8BX Newcastle Upon Tyne

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Anthea Morris (Ms.)
KITE INNOVATION (EUROPE) LIMITED
United Kingdom
EU contribution
€ 130 400
Address
3m Buckley Innovation Centre
HD1 3BD Huddersfield

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Derek Mckenzie (Mr.)