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Pathogenesis and transmission of influenza virus in pigs

Objective

FLUPIG aims at a better understanding of the role of pigs in influenza pandemics. Pandemic influenza viruses come from wild birds, but they must adapt to efficient replication and transmission in humans to cause a pandemic. Pigs are considered important intermediate hosts in which avian viruses adapt to mammals before they transmit to humans. However, the exact role of pigs is unclear, as is the nature of the genetic changes that are required for (a) efficient replication of an avian virus in pigs, (b) efficient transmission of avian viruses between pigs and (c) virus transmission from pigs to humans and between humans. The FLUPIG consortium will examine both the role of adaptive mutations and genetic reassortment. In addition, we will study the role of host and environmental factors in adaptation of avian influenza viruses to pigs. The occurrence and severity of a pandemic also depends on the immune status of the human population. The FLUPIG consortium will study the extent of cross-protection between antigenically different influenza viruses of the H1N1 subtype (heterovariant cross-protection), and between influenza viruses belonging to different haemagglutinin subtypes (heterosubtypic cross-protection). We will also study the immune mechanisms required for a broad cross-protection. In addition, we will evaluate the capacity of novel generation vaccines to broaden cross-protection. Most studies will be performed in pigs or other relevant animals, or in explants of the porcine and human respiratory tract, which show maximal similarity to the in vivo situation. Our studies will enable us to advice public health authorities about the role and risk of the pig in the emergence of novel influenza viruses in the human population. Combined with improved surveillance for influenza in animals, effective vaccines and antivirals, this knowledge will be critical to the control of future influenza pandemics.

Field of science

  • /medical and health sciences/health sciences/public and environmental health
  • /natural sciences/biological sciences/microbiology/virology
  • /medical and health sciences/health sciences/epidemiology/pandemics
  • /medical and health sciences/health sciences/infectious disease/RNA virus/influenza
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug/vaccines

Call for proposal

FP7-INFLUENZA-2010
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

UNIVERSITEIT GENT
Address
Sint Pietersnieuwstraat 25
9000 Gent
Belgium
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 005 499
Administrative Contact
Karen Van Der Meulen (Dr.)

Participants (9)

ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELLE VENEZIE
Italy
EU contribution
€ 400 000
Address
Viale Dell Universita 10
35020 Legnaro
Activity type
Other
Administrative Contact
Ilaria Capua (Dr.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 353 063
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tatjana Palalic (Ms.)
Food and Environment Research Agency
United Kingdom
EU contribution
€ 500 000
Address
Area 1A, Nobel House, Smith Square 17
SW1P 3JR London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Lucinda Cranham (Ms.)
PHILIPPS UNIVERSITAET MARBURG
Germany
EU contribution
€ 375 000
Address
Biegenstrasse 10
35037 Marburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christian Veldman (Dr.)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 500 800
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wim Leep (Mr.)
PANSTWOWY INSTYTUT WETERYNARYJNY - PANSTWOWY INSTYTUT BADAWCZY
Poland
EU contribution
€ 324 960
Address
Partyzantow 57
24100 Pulawy
Activity type
Research Organisations
Administrative Contact
Iwona Markowska - Daniel (Prof.)
HKU - Pasteur Research Centre Limited
Hong Kong
EU contribution
€ 375 150
Address
1-3/F Dexter H.c. Man Building Sassoon Road 8
HKG Pokfulam Hong Kong
Activity type
Research Organisations
Administrative Contact
Malik Peiris (Prof.)
KANSAS STATE UNIVERSITY
United States
EU contribution
€ 499 980
Address
Fairchild Hall 2
66506-1103 Manhattan Ks
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Lowe (Mr.)
FRIEDRICH LOEFFLER INSTITUT - BUNDESFORSCHUNGSINSTITUT FUER TIERGESUNDHEIT
Germany
EU contribution
€ 520 000
Address
Sudufer 10
17493 Greifswald-insel Riems
Activity type
Research Organisations
Administrative Contact
Thomas C. Mettenleiter (Prof.)