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Molecular Recognition: Understanding Proteins Adsorption to Inorganic Surfaces

Objetivo

Understanding how proteins adsorb to inorganic surfaces is important in many biotechnological applications, including the design of medical implants, fabrication of antibacterial surfaces and biomeneralization. Many studies have been carried out in order to examine how proteins interact with inorganic entities or surfaces; still, it is not clear how proteins “sense” the inorganic surface. The aim of the proposed research is get insights into the fundamental rules that govern protein adsorption.
The approach will combine the use of two powerful tools: atomic force spectroscopy and self-assembled monolayers. It will undertake a reductionist methodology and study the adsorption of individual amino acids to chemically well-defined surfaces, functionalized with self-assembled monolayers, using single-molecule spectroscopy.
The experimental approach that will be developed, in the course of the project, will be useful as a tool for other researches in the field. Additionally, findings from this research will allow the design of antibacterial surfaces, new biomaterials and peptides that interact with inorganic surfaces or particles in a controlled manner to form composite materials.

Convocatoria de propuestas

FP7-PEOPLE-2010-RG
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Coordinador

THE HEBREW UNIVERSITY OF JERUSALEM
Aportación de la UE
€ 100 000,00
Dirección
EDMOND J SAFRA CAMPUS GIVAT RAM
91904 Jerusalem
Israel

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Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Hani Ben Yehuda (Ms.)
Enlaces
Coste total
Sin datos