Objectif New exogenous molecular probes have been used in the optical imaging field. We have already developed a multi-frequency & multispectral optical tomography animal imaging system. The system has been integrated to a magnetic resonance imaging (MRI) system. In this project, we will expand our hybrid system to measure dynamic information from exogenous probes. This system would measure the enhancement kinetics of the bi-functional optical/MR or mono-functional optical contrast agents and the endogenous contrast due to hemoglobin contents and scattering properties. There are two parts of the proposal. In the first part, we will development a novel multi-modality dynamic imaging system. Inthe second part, we will develop polymer based bi-functional and mono-functional optical agents. Such a hybrid system would facilitate the development of new contrast agents for biomedical imaging and that the development of polymer based molecular agents will provide a potential new molecular platform for these new contrast agents. At the end of this project, we will be able to test our hypothesis that “the parameters obtained bymacromolecular optical agent together with total hemoglobin, oxygen saturation and tissue scattering parameters can achieve a higher specificity in differentiating between ENU induced malignant and benign tumors compared to MRI parameters measured by low molecular weight extracellular MRI agents”. Champ scientifique natural scienceschemical sciencespolymer sciencesmedical and health sciencesclinical medicineoncologyengineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imaging Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2009-RG - Marie Curie Action: "Reintegration Grants" Appel à propositions FP7-PEOPLE-2010-RG Voir d’autres projets de cet appel Régime de financement MC-IRG - International Re-integration Grants (IRG) Coordinateur BOGAZICI UNIVERSITESI Contribution de l’UE € 100 000,00 Adresse BEBEK 34342 Istanbul Turquie Voir sur la carte Région İstanbul İstanbul İstanbul Type d’activité Higher or Secondary Education Establishments Contact administratif Gulay Barbarosoglu (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
