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Bioproduction of pharmaceutically important iridoids: systems biology based approach

Project information

Grant agreement ID: 252558

Status

Closed project

  • Start date

    24 September 2010

  • End date

    23 March 2012

Funded under:

FP7-PEOPLE

  • Overall budget:

    € 128 151,40

  • EU contribution

    € 128 151,40

Coordinated by:

UNIVERSITEIT LEIDEN

Netherlands

Objective

Plant in vitro technologies have been known for more than century. During this time, plant cell, tissue and organ cultures have become increasingly attractive and cost-effective alternatives to classical approaches for the mass production of plant metabolites. Furthermore, plant in vitro systems are the only economically feasible way of producing some high-value metabolites from rare and/or threatened plants. The progress in this field has resulted in the mass production of several important metabolites, such as taxol (paclitaxel), shikonin and berberine by different companies. However, for their production several problems had to be overcome, mainly connected with their cultivation in vitro and high sensitivity to different stress factors/conditions. Today in the postgenomic era, new functional genomic tools (transcriptomics and proteomics), enabling comprehensive investigations of biological systems, are continuously further developing and are gradually being implemented in the field of plant secondary metabolism. The latest of the “omics” is metabolomics, which is now combined with the other “omics” and such a holistic functional genomic approach forms systems biology, in which the synergism of this powerful combination opens novel avenues to fully explore the total biochemical machinery of plants. The general objective of the scientific project is to evaluate the systems biology based approach for bioproduction of pharmaceutically important iridoids from difficult-to-access and endemic Bulgarian plant species. This includes transcriptomic analyses, metabolomics and assessment of biological activities. The metabolic engineering aspects will be also covered through gene/multigene transformations. The project will finally seek for development of technology platform for iridoids production in the green cell factory.
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Coordinator

UNIVERSITEIT LEIDEN

Address

Rapenburg 70
2311 Ez Leiden

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 128 151,40

Administrative Contact

Ton Brouwer (Mr.)

Project information

Grant agreement ID: 252558

Status

Closed project

  • Start date

    24 September 2010

  • End date

    23 March 2012

Funded under:

FP7-PEOPLE

  • Overall budget:

    € 128 151,40

  • EU contribution

    € 128 151,40

Coordinated by:

UNIVERSITEIT LEIDEN

Netherlands